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This study found that among older men, lower calculated free testosterone was significantly associated with a higher risk of heart failure, suggesting a possible role of testosterone deficiency in heart failure incidence.

In this study, researchers found that the pCLCA2 protein is expressed in specific areas of pig skin, but its role in skin structure or function remains unclear.

This review discusses the use of microbial biosurfactants as a safer alternative to chemical surfactants in cosmetics due to their antibacterial, moisturizing, and low toxicity properties, but it reports no new clinical findings.

This study found that corin, a protease, plays a crucial role in eccrine sweat glands by promoting sweat and salt excretion, which helps regulate electrolyte balance.

This review discusses the development and clinical progression of PROTAC technology for targeted protein degradation, highlighting its potential to address previously "undruggable" targets but reports no new clinical results.

This review discusses the pharmacology, toxicology, and clinical efficacy of flavonoids and saponins, highlighting the need for more data on their pharmacokinetics, interactions, and toxicities as most research is still in vitro.

This review examines compounds that activate IK1 channels, highlighting their potential for developing Kir channel agonists and addressing safety concerns, but does not report new experimental findings.

This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.

This article reviews 27 small-molecule drugs approved by the FDA in 2024, noting that among them, eight "first-in-class" drugs with breakthrough therapy status show distinct mechanisms and substantial efficacy improvements in various conditions like cancer and chronic diseases.

This systematic review found that antiandrogens do not appear to protect against SARS-CoV-2 infection or reduce COVID-19 severity, suggesting their use is not advisable for COVID-19 treatment.

This source reports on advances in stimulus-responsive nanoparticle-based PROTACs (nano-PROTACs), which aim to overcome existing challenges like poor cell permeability and systemic off-target effects by enabling controlled protein degradation through endogenous or exogenous stimuli, potentially enhancing therapeutic efficacy and reducing toxicity.

This review emphasized the significance of biliary fibrosis in hepatobiliary disorders, exploring its clinical manifestations, epidemiology, and cellular factors, and provided insights into current clinical trials and strategies for managing fibrosis-related cholangiopathies.

This animal study found that testosterone treatment increased vas deferens fluid secretion rate in rats, with potential implications for male fertility through the upregulation of AQP-1, 2, and 9 proteins.

This article describes the potential applications of myoblast implantation for muscle regeneration and its promising social and economic value but reports no new clinical results.

This review summarizes the state of organoid technology, highlighting its potential to transform biomedical research and regenerative medicine by providing accurate models for disease study, drug discovery, and potentially developing functional organs for transplantation.

This review detailed the significant progress and challenges in the design and application of PROTACs, a novel class of cancer therapeutics, highlighting their clinical trials, design complexities, and the role of artificial intelligence in improving their efficacy and selectivity for cancer therapy.

This review highlights potential negative impacts of certain medications on male fertility, such as hormonal disruption and germ cell toxicity, emphasizing the importance of clinicians being aware of these effects to advise on safer alternatives.

This review discusses sex-related differences in antihypertensive treatment and reports original data showing better blood pressure control in women than men until their late sixties, when the trend reverses.

This review discusses the roles of resident macrophages in the liver and lung, emphasizing their unique contributions to maintaining tissue homeostasis and the interface between circulation and external environments, but reports no new findings.

Evaluate and manage androgen excess in women with a systematic approach, considering both physical and psychological impacts.

This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.

This review highlights the inadequacy of the "specificity paradigm" in drug design for complex diseases like Alzheimer's and cancer, suggesting a shift toward developing multitarget drugs to improve treatment efficacy by interacting with multiple targets through various mechanisms.

This review discusses the patterns and regulatory mechanisms of keratin expression in various biological conditions and reports no new experimental results.

This review discusses the roles of extracellular vesicles in skin health and disease and reports no clinical results; the authors highlight potential therapeutic uses and call for more research.

This Mendelian randomization study reports that lifelong increased free testosterone in males was associated with improved bone mineral density and body composition but increased risks of prostate cancer, hypertension, and several other conditions.

This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.

This study found no significant gene expression differences in the lesional scalp of patients with central centrifugal cicatricial alopecia with and without a history of uterine leiomyomas.

The authors concluded that establishing and standardizing methods for data collection are crucial to improving PCOS diagnosis and research due to challenges observed in data harmonization across diverse international cohorts.

This review discussed the variability in measuring serum testosterone levels and emphasized the need for standardizing testing and sharing updated treatment protocols to manage male hypogonadism effectively. It also highlighted the importance of considering secondary hypogonadism causes and suggested consulting with endocrinologists for optimal management.

This study observed that numerical chromosomal aberrations were more common in men with severe male factor infertility and azoospermia compared to those with other sperm quality issues, while chromosomal translocations were significantly associated with oligoasthenozoospermia, highlighting important genetic counseling considerations.