Recent Insights in Multi-Target Drugs in Pharmacology and Medicinal Chemistry

The review discusses the limitations of the "specificity paradigm" in drug design, which has led to resistance and decreased effectiveness in treating complex diseases like Alzheimer's, Parkinson's, and cancer. It highlights the necessity for developing multitarget drugs that interact with multiple targets through various mechanisms. The document provides an overview of the methods and reactions used in the synthesis of multitarget drugs, their applications, and recent research advancements in this area.