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Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Lower SHBG levels may increase the risk of PCOS.

Growth factors are crucial for hair development and could help treat hair diseases.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Neurosteroids show promise for treating epilepsy and more research is needed.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Spironolactone can reduce hair growth in women with hirsutism.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Certain drugs that block specific enzymes can help treat prostate diseases.

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Topical JAK inhibitors may help treat alopecia universalis by promoting hair regrowth.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.