9 citations
,
November 2021 in “Frontiers in Cell and Developmental Biology” This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by alleviating ROS-mediated DNA damage, rather than enhancing DNA repair.
7 citations
,
January 2024 in “Cancer Research Communications” This study found that TAp63 and ΔNp63 isoforms in the p63 family interact with different transcription factors to regulate distinct transcriptional programs, affecting various biological functions like metabolic pathways, oxidative stress response, and epithelial morphogenesis in mouse epidermal cells.
7 citations
,
January 2017 in “Stem Cells International” This review categorizes current research on neural organogenesis and highlights potential future applications for treating central nervous system diseases, but reports no new clinical results.
6 citations
,
November 2023 in “Chinese Medicine” This study found that Xinyang Tablet may improve cardiac function in LPS-induced sepsis-induced myocardial dysfunction by modulating macrophage polarization and autophagy through affecting LncSICRNT1 and TRAF6 expression.
6 citations
,
April 2012 in “PloS one” This study used transgenic mice to show that disrupting TGF-β signaling in K14+ progenitor cells led to increased stem cell proliferation in the tongue.
4 citations
,
November 2022 in “Frontiers in Immunology” This review discusses the roles of resident macrophages in the liver and lung, emphasizing their unique contributions to maintaining tissue homeostasis and the interface between circulation and external environments, but reports no new findings.
4 citations
,
January 2021 in “in Vivo” This study found that scoparone increased the expression of certain pluripotency-related proteins in dermal papilla cells, suggesting a potential new mechanism for enhancing hair growth.
3 citations
,
January 2012 in “Journal of Investigative Dermatology” Inhibiting PGD2 and using dermal papilla cells may improve skin and hair regeneration.
1 citations
,
May 2022 in “Frontiers in Pharmacology” This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.
This source reviews current understanding of fibroblast lineage differentiation and its role in wound healing, highlighting the potential to reprogram adult cells for scar-free repair by emulating fetal-like regenerative states.
November 2025 in “Photochemistry and Photobiology” This review article identifies a need for standardized guidelines in using photobiomodulation therapy for spinal cord injury repair, emphasizing that current inconsistencies in therapy parameters may hinder optimal outcomes and limit clinical trials.
August 2025 in “Journal of Polymer Science” This review reports that combining adipose-derived stem cells with decellularized extracellular matrix enhances tissue repair by improving scaffold biological activity and promoting angiogenesis, integration, and functional regeneration across various tissues, while addressing challenges in traditional transplantation methods.
April 2025 in “International Journal of Molecular Sciences” In this study, exosomes derived from Iris germanica L. rhizomes (Iris-exosomes) were reported to alleviate oxidative stress and improve mitochondrial function in human follicle dermal papilla cells by activating the Wnt/β-catenin signaling pathway, suggesting potential benefits for hair loss treatment.
November 2024 in “Clinical Nutrition Open Science” This study reports that in mesenchymal cells, the effect of resveratrol on cell viability and metabolic enzyme activity varied with dosage and exposure time, with high doses promoting bone differentiation and potentially benefiting mesenchymal cell health and differentiation into osteoblasts.
April 2024 in “International journal of molecular sciences” This study examines the similarities and differences in the pathogenesis of autoimmune conditions alopecia areata and vitiligo, highlighting shared features like immune cell involvement and cytokine pathways, while noting differing immune responses in skin and hair.
January 2025 in “Stem Cells International” In this review, researchers discuss the role of epigenetic modifications in epidermal stem cells' decline during skin aging and identify potential interventions targeting these disruptions, suggesting significant possibilities for antiaging strategies and dermatological treatments.
9 citations
,
February 2022 in “Biomolecules” This review concludes that while many epidemiological studies suggest high alcohol intake is associated with an increased risk of prostate cancer, the evidence may be affected by confounding factors such as diet and lifestyle.
June 2024 in “Computational and Structural Biotechnology Journal” This review discusses the integration of omics analyses in androgenetic alopecia research, reporting no new clinical results but suggesting that collaborative multi-omics studies may enhance understanding of AGA's pathomechanisms.
6 citations
,
April 2010 in “Cellular Reprogramming” The study characterized the transcriptional changes in porcine SKP cells transitioning to fibroblast-like cells, indicating potential roles for specific signaling pathways in this cell fate transition.
76 citations
,
July 2019 in “Cellular and Molecular Life Sciences” This article reviews the role of stem cells in tissue development, tumor formation, and organoid generation, and highlights the potential of epigenetic regulation in advancing regenerative medicine and cancer treatment, without presenting new experimental results.
471 citations
,
October 2012 in “Cellular and Molecular Life Sciences” This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.
41 citations
,
September 2012 in “Cellular and Molecular Life Sciences” This review summarizes the current understanding of microRNAs in skin biology, highlighting their roles in processes like wound-healing and aging, without presenting any new experimental results.
April 2026 in “Cellular and Molecular Immunology” In a conditional knockout mouse model, this study found that loss of the transcription elongation factor SPT6 in basal keratinocytes led to psoriasis-like skin inflammation and delayed wound healing, suggesting SPT6 plays a crucial role in maintaining epidermal immune quiescence by suppressing proinflammatory NF-κB signaling.
47 citations
,
October 2016 in “Molecular and Cellular Endocrinology” This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.
44 citations
,
June 2018 in “Journal of Cellular Physiology” This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.
14 citations
,
August 2018 in “Frontiers in Cellular and Infection Microbiology” This study found that dengue virus infection caused inflammation and cell death in human hair-follicle dermal papilla cells, which may contribute to increased hair shedding observed during the epidemic in Taiwan.
22 citations
,
July 2016 in “Cellular and Molecular Life Sciences” Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.
27 citations
,
February 2023 in “Oxidative Medicine and Cellular Longevity” This study found that platelet-derived mitochondria can promote wound healing by reducing oxidative stress-induced apoptosis in vascular endothelial cells, with survivin identified as a potential target.
9 citations
,
March 2019 in “Molecular & cellular proteomics” In this study, around 1% of proteins in skin fibroblasts significantly changed in response to reductive stress, affecting collagens and MAPK signaling pathways.
1 citations
,
June 2023 in “Journal of Cellular and Molecular Medicine” This study observed that tissue-engineered skin, using VEGF165 gene-modified cells embedded in astragalus polysaccharide-containing 3D printed scaffolds, enhanced early vascularization, and collagen and hair follicle regeneration, leading to improved skin repair in nude mice with full skin defects.