The Effect of Resveratrol on the Viability of Rat Bone Marrow Mesenchymal Stem Cells

November 2024 in “ Clinical Nutrition Open Science ”

Fatemeh Ghasemi, RozaSadat RezaTofighi, Mohammad Moradiani Moradabadi, Mona Zamanpour, Michael Aghcheli, Mohammad Amin Ebrahimi, Ali Khatib, Fatemeh ashabi

TLDR High doses of resveratrol improve bone cell health and differentiation.

This study examined the effects of resveratrol on rat bone marrow mesenchymal stem cells (MSCs), revealing that resveratrol's impact is dose-dependent. Low doses did not affect MSC viability, while higher doses (15 and 30 mg/L) enhanced osteogenic differentiation, mineralization, and bone differentiation. Significant increases in calcium deposition and alkaline phosphatase activity were observed at higher doses, particularly after 5 and 10 days. However, prolonged exposure to high doses can negatively affect MSC viability. The study suggests resveratrol's potential benefits for bone health and regenerative medicine, though further research is needed to fully understand its cellular mechanisms.

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Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

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