Effects of MRI on Stemness Properties of Wharton's Jelly Derived Mesenchymal Stem Cells

    November 2021 in “ Research Square (Research Square) ”
    Mahnaz Tashakori, Fatemeh Asadi, Faezeh-Sadat Khorram, Azita Manshoori, Ali Hosseini‐Chegeni, Mahdieh Ahmadi Kamalabadi, Aliakbar Yousefi‐Ahmadipour
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    Studysummary This study observed that MRI treatment increased expression of stemness-related genes and colony formation in umbilical cord-derived mesenchymal stem cells without affecting viability or apoptosis, suggesting enhanced quality for therapeutic use.
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    This study investigated the effects of MRI on the stemness properties of Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs). The results showed that MRI treatment significantly increased the expression of stemness genes SOX-2 and NANOG by 32- and 213-fold, respectively. Despite the increased doubling time, the viability and apoptosis rates of the cells remained unchanged. Additionally, the colony formation ability of WJ-MSCs improved post-MRI treatment. These findings suggested that MRI could enhance the quality and potential efficacy of mesenchymal stem cell-based therapies.
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