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Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.

Th22 cells are essential for Tβ15-induced hair growth in mice.

RANKL improves the immune response against herpes simplex virus by enhancing T cell activation and could help develop better treatments or vaccines.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

M-CSF-stimulated myeloid cells can cause alopecia areata in mice.

A specific DNA region is crucial for Foxn1 gene expression in thymus cells but not in hair follicles.

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

Using low-dose IL-2 to increase regulatory T cells might be a safe way to treat type 1 diabetes without severe side effects.

Understanding how Regulatory T Cells work could help create treatments for certain skin diseases and cancers.

NK cells play a role in skin diseases like eczema and psoriasis.

Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.

New treatments for hair loss from alopecia areata may include targeting immune cells, using stem cells, balancing gut bacteria, applying fatty acids, and using JAK inhibitors.

Androgenetic alopecia involves immune cell disruptions, especially increased CD4+ T cells around hair follicles.

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

Alopecia areata involves complex immune and genetic factors, with potential treatment targets identified, but more research is needed.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

New treatments targeting immune pathways show promise for severe hair loss but need more research for safety and effectiveness.

Botulinum toxin type A significantly reduces scalp psoriasis severity compared to placebo.

Fat tissue under the skin affects hair growth and aging; reducing its inflammation may help treat hair loss.

New therapies are being developed that target integrin pathways to treat various diseases.

Japanese patients with alopecia areata often have a higher BMI and consume more vitamin C, fruit, and retinol, which may affect their condition's development or severity.

No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

Treg dysfunction is linked to various autoimmune skin diseases, and understanding Treg properties is key for new treatments.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.