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This study found that anionic HSES achieved high complexation efficiencies with various steroids, significantly enhancing their solubility, while specific β-cyclodextrin thioethers showed selective binding to testosterone and estradiol.

This study found that 5 alpha-dihydrotestosterone increased pigmentation in dorsal spots and scrotal skin of prepubertal male Syrian hamsters, while estradiol decreased scrotal skin melanocytes and reversed androgen-induced pigmentation in costovertebral spots.

This article discusses treatments for androgenic manifestations using cyproterone acetate alone or with estrogens, but it does not provide new clinical results.

This study found that novel androgen antagonists incorporating a carborane moiety showed anti-androgenic activity comparable to flutamide in a laboratory setting.

This study found that CPA-loaded nanoparticles, particularly SLN formulations, increased CPA epidermal penetration compared to a conventional cream and may reduce side effects in treating androgen-dependent conditions.

This study found that carvone, a plant-derived compound, decreases melanin content and inhibits melanoma cell proliferation through the cAMP pathway, suggesting potential benefits for treating melanomas and other hyperpigmentation disorders.

This study found that camphor and similar compounds depress neural activity in rat mechanoreceptors, suggesting that their effects may not be mediated through TRP channels.

This review summarizes the use of chlormadinone acetate for hormone replacement therapy and contraception, highlighting its anti-androgenic effects, contraceptive efficacy, and clinical tolerability, without offering new clinical results.

This study found that tribuloside, a flavonoid from Tribulus terrestris L., enhances melanin production in human melanocytes, zebrafish, and human skin samples without causing toxicity, potentially through inhibiting PDE to increase cAMP levels and promote the melanin biosynthesis pathway.

This study found that impairments in cholesterol biosynthesis in hair follicles of primary cicatricial alopecia patients trigger an inflammatory immune response, potentially linking sterols to inflammation in the disease's pathogenesis.

This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.

In this study using fertilized chicken eggs, researchers reported that ethanol and aqueous extracts of clove, cinnamon, and coriander significantly reduced blood vessel formation, indicating these herbs' potential as safe anti-angiogenic treatments without severe side effects compared to synthetic drugs.

In this study, TRPV1 signaling was found to play a critical, previously unrecognized role in human sebocyte biology, and targeting this pathway may offer a new approach for managing inflammatory sebaceous gland disorders like acne.

This animal study found that Cinnamomi cortex water extract reduced prostate weight and improved histological changes in a benign prostatic hyperplasia model, suggesting potential as a treatment.

This study developed a sensitive HPLC-MS/MS method for determining cyproterone acetate levels in human plasma and found no significant difference in its concentration between two oral formulations in bioequivalence testing.

This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.

This study found that Prosopis farcta is a rich source of phenolic compounds with strong antioxidant activity, suggesting its potential for use in food, beverage, feed, and pharmaceutical applications.

This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.

This phase 2a trial evaluated Samcyprone for common wart treatment and found that while a sensitization reaction is necessary for therapeutic response, its level does not predict wart clearance.

In this study, cyproterone acetate combined with estradiol dramatically improved hirsutism symptoms and significantly reduced plasma testosterone and androstenedione levels in patients over periods of up to three years.

This study identified that the biosynthetic pathways for coumestans in Eclipta prostrata are derived from acetate and shikimate pathways, while phenylpropanoid biosynthesis is exclusively from the shikimate pathway.

This review examines androgen status in male and female obesity and its influence on the metabolic syndrome, but reports no new clinical results.

This study found that oral treatment with Chamaecyparis obtusa var. formosana leaf extracts improved glucose metabolism and reduced insulin resistance in hyperglycemic rats, suggesting potential as a diabetes health supplement.

This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

In this study, the n-hexane fraction of Carthamus oxyacantha methanolic extract exhibited significant 5α-reductase inhibitory activity in vitro, suggesting potential therapeutic use for benign prostatic hyperplasia through DHT inhibition.

This study found that a polyherbal sunscreen cream, F4, containing Camellia sinensis, Vitis vinifera, and Silybum marianum extracts demonstrated strong antioxidant and photoprotective properties, similar to synthetic sunscreens.

This study developed a method using LC/APCI-MS to measure the activity of steroid 5α-reductase, applied to kinetic studies and inhibitory tests with Finasteride in a rat prostatic enzyme model.

This study found that cyproterone acetate significantly reduced both serum 3α-AdiolG levels and hirsutism scores in women with idiopathic hirsutism, PCOS, or 21-hydroxylase deficiency, suggesting its effectiveness in treating excessive hair growth.

This study developed an advanced HPLC-ESI-ion trap MS(n) method for the structural identification of cyclosporin A analogs CyA and CyC and reported the first MS(n)-aided identification of a new CyA analog.