The New Director of Technology
January 2004
in “
Banca y finanzas: Revista profesional de gestión financiera
”
New to Estradiol? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that 5 alpha-dihydrotestosterone increased pigmentation in dorsal spots and scrotal skin of prepubertal male Syrian hamsters, while estradiol decreased scrotal skin melanocytes and reversed androgen-induced pigmentation in costovertebral spots.
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The study analyzed the effects of 5 alpha-dihydrotestosterone and estradiol-17 beta on pigmentation in prepubertal male Syrian hamsters. It found that 5 alpha-dihydrotestosterone increased pigmentation in costovertebral spots and scrotal skin without changing the percentage of pigmented area, while estradiol decreased the number of scrotal skin melanocytes in intact animals. The androgen-induced pigmentation was reversed by estradiol, suggesting that androgenic stimulation of pigmentation is direct, occurs before puberty, is tissue-specific, and can be antagonized by estrogens. The differential response of melanocytes may be due to changes in premelanin oxidation, melanocyte size and shape, or melanin synthesis rate.
