Finasteride Inhibits Melanogenesis Through the Regulation of Melanocortin 1 Receptor in Melanocytes

The study investigated the effects of finasteride, a drug commonly used for treating alopecia and prostate cancer, on melanogenesis in melanocytes. Finasteride is known to reduce dihydrotestosterone (DHT) levels by inhibiting 5α-reductase activity. The research aimed to explore how finasteride affects melanin synthesis and skin pigmentation through the regulation of the melanocortin 1 receptor (MC1R), a protein involved in skin and hair color regulation. Various concentrations of finasteride (1, 10, 20, and 100 µM) were tested on melanocyte and melanoma cells to assess its impact on melanin production. The study provided insights into the potential role of finasteride in influencing pigmentation processes.