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This review discusses the therapeutic potential of Smoothened modulators for cancer treatment and explores their pharmacological implications, but reports no new clinical findings.

This review discusses factors affecting hair health, types of alopecia, and the potential of phytochemicals in managing hair loss but reports no new clinical results; it highlights the need for further studies.

In this study, the researchers found that cholinergic signaling via M4 muscarinic receptors influences hair growth, with enhanced elongation observed upon activation with bethanechol, highlighting its potential role in hair biology using mouse models.

In this study, researchers identified key genes such as EDNRB2, GPNMB, TRPM1, TYR, and DCT that regulate melanin deposition in the breast muscles of black-boned chickens, contributing to their unique pigmentation during embryonic development.

This study found that topical rebamipide, originally a gastric ulcer medication, can activate hair follicle stem cells and promote hair regeneration by modulating dermal adipocyte metabolism, with potential targeting of the prostaglandin E receptor EP4.

This review summarizes recent progress in microneedle-based drug delivery systems and discusses their potential impact on cellular mechanisms and immunization signaling pathways, highlighting the need for further development in fabrication methods.

In this narrative review, researchers synthesized current evidence on topical metformin's potential benefits for various skin conditions, citing primarily preclinical studies that highlight its anti-inflammatory, antioxidant, and regenerative properties, although clinical translation requires further rigorous trials.

This review explores melatonin's role in hair follicle cycles and its molecular mechanisms that enhance antioxidant capacity and modulate gene expression, offering potential strategies to improve cashmere production and treating human alopecia, according to the authors.

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

This review explores the complex biological process of hair graying, highlighting oxidative stress, genetic factors, and interventions like antioxidants and genetic therapy as key aspects affecting the preservation of hair pigmentation.

This review discusses the role of lysophosphatidic acid in skin physiology and pathology, highlighting its significance in processes like wound healing and hair follicle development, but reports no new clinical findings.

This review discusses the therapeutic properties of polydeoxyribonucleotides derived from marine organisms for wound healing and inflammation, but it reports no new clinical results.

This review identifies and discusses various endocrine-related causes of hypertension in children and adolescents, emphasizing the role of genetic predispositions and highlighting the need for systematic diagnostic guidelines and genetic sequencing referrals to improve diagnosis and treatment strategies.

This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.

This review discusses current and emerging therapeutic strategies for androgenetic alopecia, noting limited evidence but suggesting areas such as prostaglandin analogs, PRP, and progenitor cell therapies as promising future directions.

This review provides an analysis of topical treatments with clinically proven efficacy for managing hyperpigmentation and concludes that the most effective approach is using combined therapies that target multiple aspects of skin pigmentation physiology.

In this study, researchers identified 19 genetic risk loci and highlighted 16 candidate causal genes, including immune-related ones, associated with polycystic ovary syndrome, emphasizing the role of specific immune cells like T cells and NK cells in its pathogenesis.

This review explores the challenges of treating chronic wounds and highlights regenerative medicine as a promising approach, emphasizing the roles of growth factors, stem cell therapies, and novel regenerative treatments in improving wound healing and tissue regeneration.

This article discusses the role of estrogens in skin aging and reports no new findings; it highlights the potential of selective ER modulators to improve skin health without systemic side effects.

This review explores the role of Panx3 in skeletal formation and discusses its potential in developing new therapies for conditions like osteoarthritis, without presenting new clinical findings.

This study used computational modeling to identify key genes and miRs involved in cardiac aging, finding a strong relationship supported by literature and some experimental validation in aged mouse hearts.

This article discusses melanocyte development from neural crest cells and reports no new experimental results; the authors suggest a broader range of functions for melanocytes than previously recognized.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.

This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.

This review discusses the roles of prostaglandins in the nervous system and their therapeutic potential for neurological diseases, noting their complex interactions with immune cells and signaling pathways.

This study suggests that in gp91phox-knockout mice, tranexamic acid administration led to brown hair by increasing MGRN1 and collagen XVII levels, while the retention of black hair appears to rely on the gp91phox/ROS/IL-1β/TGF-β pathway.

This review discusses how various nutrients, such as flavonoids, probiotics, and omega-3 fatty acids, may support brain health by targeting stress-related pathways, potentially offering protective effects against neurodegenerative and psychiatric disorders through their roles in oxidative stress reduction and neuroinflammation regulation.

This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.

In this review, researchers explored key mechanisms underlying androgenetic alopecia, revealing how hormonal, oxidative, inflammatory, and lipid dysregulation suppress hair growth pathways and suggesting new therapeutic targets such as DP2 antagonists and microbiome modulators.