19 citations
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July 2018 in “Medicines” This review highlights the pharmaceutical potential of secondary metabolites from Juniperus species, noting promising antitumor, antibacterial, and antiviral activities, but reports no new experimental findings.
19 citations
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November 2017 in “Journal of Pharmaceutical Sciences” This research investigated aqueous alginate-based hydrogels for delivering minoxidil and reported that using hydroxypropyl-β-cyclodextrin (HP-β-CD) with molar substitution 0.65 significantly enhanced minoxidil's solubility and skin permeability without damaging the epidermis, suggesting potential as an alternative to commercial minoxidil solutions.
18 citations
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March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, 17β-estradiol increased VEGF production in differentiated THP-1 cells, while dihydrotestosterone counteracted this effect by modulating adenylate cyclase activity.
17 citations
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March 2021 in “Expert Opinion on Biological Therapy” This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.
17 citations
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June 2019 in “Cellular signalling” Minoxidil treatment in mice preserved the integrity of elastic lamellae and improved arterial biomechanical properties, especially in females, suggesting it could be an anti-arterial aging agent potentially suitable for female-targeted therapies.
15 citations
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June 2014 in “Integrative cancer therapies” This study found that an 8-week practice of pranic meditation was associated with improved quality of life and mental health scores in breast cancer survivors, though further research is needed for confirmation.
14 citations
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October 2016 in “Psychoneuroendocrinology” This study identified significant changes in the expression of nine proteins in the nucleus accumbens of rats treated with finasteride, suggesting potential novel targets for its neuropsychiatric effects.
11 citations
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April 2013 in “Journal of Proteomics” This study identified proteins that are differentially expressed in balding versus non-balding dermal papilla cells, potentially aiding the understanding and treatment of androgenetic alopecia.
10 citations
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January 2024 in “Polymer Chemistry” This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.
8 citations
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June 2012 in “PloS one” This study found that the Plcd3(mNab) mutation in mice worsens the alopecia caused by Plcd1 loss, suggesting synergistic effects between Plcd1 and Plcd3 on hair follicle health.
6 citations
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September 2024 in “Frontiers in Physiology” This study found that overexpression of R-spondin 3 in a mice model impaired hair morphogenesis and regeneration by reducing hair matrix progenitor cell proliferation, thus disrupting the Wnt pathway's regulation of stem cells.
6 citations
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May 2022 in “Aging” This study found that Si Jun Zi Tang may have anti-aging effects in mice, linked to inhibition of the PI3K-AKT and P38 MAPK signaling pathways.
3 citations
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April 2021 in “PLoS ONE” The authors concluded that controlling voltage, pulse width, and calcium concentration in pulse electric field-activated platelet-rich plasma enhances the release of growth factors and serotonin without causing clot formation, suggesting potential clinical advantages over bovine thrombin-activated PRP.
3 citations
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April 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, beta-caryophyllene enhanced wound healing in female mice by improving re-epithelialization, cell proliferation, and cell migration, suggesting potential benefits of essential oil compounds in inflammation reduction.
2 citations
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June 2024 in “Frontiers in Plant Science” This study found that RALF peptides, through liquid-liquid phase separation, form condensates with pectin and other proteins, playing a pivotal role in plant development and stress response regulation.
2 citations
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May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that stem cells can temporarily act as non-professional phagocytes during hair cycle regeneration by clearing apoptotic cells through a process requiring local lipids and retinoids for activation, providing insights into their dual role in maintaining tissue integrity.
2 citations
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January 2019 in “Medizinische Genetik” Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.
2 citations
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December 2016 in “Experimental cell research” This study reveals that CSPG4-positive basal cell keratinocytes show distinct global gene expression from CSPG4-negative cells, despite similar colony-forming efficiency.
1 citations
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June 2025 in “Frontiers in Bioengineering and Biotechnology” This review examines glycopeptide hydrogels as biomimetic materials for tissue regeneration and other biomedical applications, describing their design, properties, and potential uses, and highlighting future advancements in replicating natural tissue environments for precision medicine.
1 citations
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April 2025 in “Tropical Journal of Natural Product Research” In this study, researchers using network pharmacology and molecular docking methods found that compounds from Avicennia Marina could inhibit hepatitis C virus infection by targeting key proteins such as AKT1 and TNF-α, showing potential for anti-HCV treatments.
May 2026 in “Research Square” This research reports that the polyG fragment within the Hoxc13 protein alters its gene regulatory functions, which could have influenced mammalian hair evolution by affecting pathways related to hair follicle development.
February 2026 in “Bioimpacts” This review discusses advancements and challenges in using 3D bioprinting for diabetic foot ulcer treatments, highlighting potential improvements and existing limitations in replicating skin architecture and clinical application.
January 2026 in “Saudi Journal of Medical and Pharmaceutical Sciences” In this study, researchers developed mango pectin-based hair gels for traction alopecia in black women, finding the gels exhibited beneficial properties for hair and good stability, suggesting potential as phytocosmetic treatments without common adverse effects.
January 2026 in “The Eurasian Journal of Life Sciences” This review discusses recent advances in the development of electrospun pectin nanofibers for biomedical applications, highlighting strategies to improve their mechanical properties and biological functions and addressing challenges like material variability and regulatory issues.
January 2026 in “Cirugía Plástica .” This study reviewed preclinical evidence suggesting that topical glutamic acid can enhance hair regrowth and skin healing in burn-induced alopecia, highlighting its potential as a simple, low-cost treatment option that warrants further clinical trials.
December 2025 in “Journal of Pharma Insights and Research.” This paper reviews the state of knowledge on injectable cryogels, highlighting their unique properties such as shape-memory and mechanical integrity, which allow for minimally invasive delivery via needles and potential applications in oncology and regenerative medicine.
December 2025 in “npj Systems Biology and Applications” This study found that cold exposure disrupts the circadian rhythm in cultured human cells by reducing oscillation amplitude, which is restored upon rewarming, while human hair follicle cells showed minimal amplitude sensitivity to temperature changes, suggesting an evolutionary advantage related to Hopf bifurcation dynamics.
November 2025 in “Saudi Journal of Medical and Pharmaceutical Sciences” In this study, researchers developed and tested hair gels using pectin from mango and coconut oil as a potential natural treatment for traction alopecia in black women, reporting stability in some formulations and rheological properties that may support their use in innovative phytocosmetics.
September 2025 in “Medical Materials Research” This review explores the recent developments and diverse applications of microneedles in drug delivery and diagnostic platforms but reports no new clinical results.
This study in diabetic db/db mice found that treatment with the antihypertensive agents minoxidil or nebivolol stimulated elastogenesis and inhibited elastolysis, leading to restored elastic fibers, reduced aortic stiffening, and normalized blood pressure.