Activation of Platelet-Rich Plasma by Pulse Electric Fields: Voltage, Pulse Width, and Calcium Concentration Can Be Used to Control and Tune the Release of Growth Factors, Serotonin, and Hemoglobin

    April 2021 in “ PLoS ONE ”
    V.B. Neculaes, Andrew L. Frelinger, Anja J. Gerrits … Alan D. Michelson
    Studysummary The authors concluded that controlling voltage, pulse width, and calcium concentration in pulse electric field-activated platelet-rich plasma enhances the release of growth factors and serotonin without causing clot formation, suggesting potential clinical advantages over bovine thrombin-activated PRP.
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    Research cited in this study 4

    1. A Multi-Donor Ex Vivo Platelet Activation and Growth Factor Release Study Using Electric Pulses With Durations Up to 100 Microseconds IEEE Access · 2021
    2. Platelet-Rich Plasma: Current Applications in Dermatology PubMed · 2019
    3. Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial Dermatologic Surgery · 2018
    4. A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification Skin appendage disorders · 2017