Three-Dimensional Bioprinted Hydrogels for the Management of Diabetic Wounds: A Review

This review discusses the use of three-dimensional bioprinted hydrogels in managing diabetic foot ulcers (DFUs), a common complication affecting 15% to 20% of people with diabetes. It highlights the potential of 3D bioprinting technology to enhance therapeutic approaches by developing composite 3D skin substitutes and biological dressings that replicate native skin architecture. The review also addresses challenges such as limited vascularization, standardization issues, and scalability that hinder clinical application. It emphasizes the potential of emerging biotechnological tools and novel biomaterials to overcome these limitations and improve DFU wound management.