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research Highlights from the 68th Annual Meeting of the Society of Investigative Dermatology
The meeting discussed vitamin D3's role in fighting tuberculosis, potential treatments for skin conditions like psoriasis, and hair follicle regeneration as a possible solution for hair loss.
research The Murine Hair Follicle Is a Melatonin Target
Melatonin directly affects mouse hair follicles and may influence hair growth.
research First-In-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
research Hidradenitis Suppurativa: A Practical Review of Possible Medical Treatments Based on Over 350 Hidradenitis Patients
Different treatments for Hidradenitis suppurativa range from antibiotics and hormonal therapies to surgery, depending on severity.
research Spatiotemporal Labeling of Melanocytes in Mice
The research showed how melanocytes develop, move, and respond to UV light, and their stem cells' role in hair color and skin cancer risk.
research Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease
Zebrafish are useful for studying and developing treatments for human skin diseases.
research Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders
Exosomes could be a promising way to help repair skin and treat skin disorders.
research Antioxidant and Antiproliferative Activity of Finasteride Against Glioblastoma Cells
High-dose finasteride may help treat glioblastoma but needs localized delivery for effectiveness.
research Frequency of Dyslipidemia in Male Patients Presenting With Androgenic Alopecia at Tertiary Care Hospital, Karachi
Many men with androgenic alopecia also have dyslipidemia.
research Sorafenib Combined with Hepatectomy in Patients with Intermediate-Stage and Advanced Hepatocellular Carcinoma
Sorafenib after liver surgery may increase survival for some liver cancer patients.
research Proteomic Analysis of Balding and Non-Balding Mesenchyme-Derived Dermal Papilla Cells from Androgenetic Alopecia Patients Using Online Two-Dimensional Reversed Phase-Reversed Phase LC-MS/MS
Found different proteins in balding and non-balding cells, giving insight into hair loss causes.
research Posters Presented at the 19th Joint Meeting of the International Society of Dermatopathology, March 2–3, 2016, Hilton Crystal City at Washington Reagan National Airport, Arlington, Virginia, USA
The meeting showcased rare skin disease cases, highlighting the need for accurate diagnosis and treatment.
research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed
The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
research Mechanical Forces in Skin Disorders
Skin problems can be caused or worsened by physical forces and pressure on the skin.
research Regulation of Melanocyte Stem Cell Behavior by the Niche Microenvironment
The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.
research Molecular Pathology of Skin Adnexal Tumors
New markers and pathways have been found in skin tumors, helping better understand and diagnose them.
research Transcriptome Profiling of Whisker Follicles in Methamphetamine Self-Administered Rats
Methamphetamine affects gene expression in rat whisker follicles, with key genes linked to addiction.
research Melatonin Receptors and Their Role in Human Diseases
Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.
research Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)
Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.
research TNC+ Fibroblasts Involved in Skin Inflammation via Neuro-Immune Interactions with T Cells
TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.
research Three Streams for the Mechanism of Hair Graying
Hair graying may be caused by stem cell depletion from stress or melanocyte damage.
research Genetically Modified Laboratory Mice with Sebaceous Glands Abnormalities
Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.
research Management of Colorectal Cancer Using Nanocarrier-Based Drug Delivery for Herbal Bioactives: Current and Emerging Approaches
Nanocarriers can improve the effectiveness of herbal medicines in treating colorectal cancer.
research Genetics of Thyroid Lesions Updated
RET mutation is important in familial medullary thyroid carcinoma, and BRAF mutation in papillary thyroid carcinoma is linked to more aggressive cancer and higher death rates.
research Melanocytes: The New Black
Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.
research Hair and Nail Adverse Events During Treatment with Targeted Therapies for Metastatic Melanoma
Targeted therapies for advanced skin cancer often cause hair and nail problems, which need managing to avoid changing the treatment dose.
research Vemurafenib-Induced Pityriasis Amiantacea: A Case Report
Vemurafenib can cause scalp issues but can be managed without changing the dose.
research Dyad of Infantile Cutaneous and Thymic Langerhans Cell Histiocytosis: Is It Rare?
Thymic LCH may be underdiagnosed, so thymic ultrasound should be considered in infants with cutaneous LCH.
research Author Response: Dynamics of Nevus Development Implicate Cell Cooperation in the Growth Arrest of Transformed Melanocytes
Moles may stop growing because of cell cooperation, not just because of aging cells.