Author Response: Dynamics of Nevus Development Implicate Cell Cooperation in the Growth Arrest of Transformed Melanocytes

Ruiz-Vega and collaborators challenged the idea that nevi growth arrest is due to oncogene-induced senescence by analyzing single-cell RNA-seq data from BRAF V600E-expressing mouse melanocytes and found no evidence of senescence. Their mathematical models suggested that nevi size distribution is better explained by cooperative mechanisms similar to normal tissue size control, proposing that growth arrest in nevi is mediated by cell interactions. The reviewers found the manuscript clear and convincing. The authors addressed reviewer comments by clarifying arrest probabilities in figures, explaining Monte Carlo time steps in their modeling, and including additional analysis in the supplementary material.