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Glossary BRAF Mutation

mutation in the BRAF gene affects cell growth and division

A BRAF mutation refers to a change in the BRAF gene, which plays a crucial role in cell growth and division. This mutation can lead to uncontrolled cell proliferation and is often associated with various cancers, including melanoma, colorectal cancer, and thyroid cancer. The most common BRAF mutation is V600E, where valine (V) is replaced by glutamic acid (E) at position 600 in the protein. This mutation can be a target for specific cancer therapies, making it a significant focus in oncology.

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research Lentiginous melanoma. A clinically malignant entity that histopathologically seems benign. Case study harbouring BRAF V 600R mutation

1 citations , March 2015 in “Journal of the European Academy of Dermatology and Venereology”

This letter to the editor shares a case study of lentiginous melanoma that appears clinically malignant but histopathologically benign, involving the BRAFV600R mutation.

research Hair and nail adverse events during treatment with targeted therapies for metastatic melanoma

32 citations , May 2016 in “European journal of dermatology/EJD. European journal of dermatology”

In this study, researchers found that targeted therapies for metastatic melanoma often cause hair and nail side effects, with hair changes more common in patients treated with BRAF inhibitors like vemurafenib.

research Hair(y) Matters in Melanoma Biology

7 citations , May 2020 in “Trends in molecular medicine”

This study explored the immune environment of the hair follicle's bulge region and suggested that its unique signaling may prevent melanoma formation by lacking necessary proinflammatory signals for full oncogenic transformation, indicating potential strategies for melanoma prevention by replicating this immune-privileged environment.

research Diagnosis and Management of Melanoma of the Scalp: A Review of the Literature

3 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

This review discusses the epidemiology, risk factors, clinical features, and management of scalp melanomas, highlighting their high mortality rates and specific challenges in diagnosis and treatment; it reports no new research findings.

research Dyad of infantile cutaneous and thymic Langerhans cell histiocytosis: Is it rare?

October 2023 in “Pediatric blood & cancer”

This report discusses a potentially underdiagnosed form of multisystem Langerhans cell histiocytosis in infants, demonstrating the use of thymic sonography for staging, highlighting a case where thymic and cutaneous involvement was confirmed, and suggesting thymic ultrasound may aid in better diagnosis and management of LCH.

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