65 citations
,
September 2004 in “The American journal of pathology” This study found that overexpressing the BMP inhibitor Noggin in transgenic mice led to a significant loss of nontylotrich hair follicles, suggesting a critical role for BMP signaling in hair follicle morphogenesis and cycling.
6 citations
,
August 2020 in “Cell regeneration” This study found that hair follicle mesenchymal stem cells are similar to bone marrow stem cells in most characteristics, but differ in their adipogenic and osteogenic differentiation capabilities, suggesting they may be a suitable source for adipogenesis research.
4 citations
,
May 2019 in “Zeitschrift für Naturforschung C” This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.
1 citations
,
January 2024 in “Advances in Engineering Technology Research” This study found that bone marrow mesenchymal stem cells from Guizhou miniature pigs showed stable growth and multidirectional differentiation potential, making them ideal for tissue engineering applications.
52 citations
,
July 2011 in “PubMed” This review discusses the diverse roles of the TRPS1 gene in regulating cartilage, kidney, and hair follicle development, highlighting its functions and interactions, but provides no new experimental results.
28 citations
,
November 2013 in “Cell and Tissue Research” 21 citations
,
September 2003 in “Journal of Clinical Investigation” This paper reports that noggin inhibits BMP-2 and BMP-4 functions by binding and blocking their interaction with the BMP receptor, impacting multiple developmental processes without presenting new research results.
17 citations
,
February 2020 in “Cell and Tissue Banking” 3 citations
,
November 2020 in “PubMed” This study observed that bone marrow mesenchymal stem cells cultured in three-dimensionally bioprinted hydrogels with higher stiffness, like 3A8G, tend to differentiate more into hair follicle cells compared to those in less stiff hydrogels, like 1A4G.
7 citations
,
February 2009 in “Cell and tissue biology”
17 citations
,
November 2017 in “PLoS ONE” This study observed dynamic behaviors such as cluster formation, migration, and active proliferation of transplanted bone marrow cells in a mouse model, providing insight into cellular-level changes post-transplantation.
April 2021 in “Institutional Repositories DataBase (IRDB)” This study reported that high-intensity red LED irradiation increased osteogenic differentiation and mineralization of human bone marrow mesenchymal stem cells, potentially through Wnt/β-catenin pathway activation.
July 2025 in “Bulletin de la Banque Méllié Iran.” This study found that Spirulina algae extract significantly increased the differentiation of bone marrow-derived mesenchymal stem cells into neural cells without toxicity, suggesting potential as a therapeutic approach for neurodegenerative diseases in an in vitro setting.
18 citations
,
January 2013 in “Evidence-based Complementary and Alternative Medicine” In this study, ALR was found to enhance both the proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells, potentially through specific signaling pathways.
29 citations
,
April 2020 in “Biomolecules” The study suggests that a 3D culture system using the RAD16-I peptide scaffold can help restore the original phenotype of hair follicle dermal papilla cells and support their osteogenic and adipogenic differentiation.
125 citations
,
August 2003 in “Development” In this study, mice engineered to express human EGFR showed tissue-specific growth defects and neurodegeneration rescue, but developed severe heart issues and accelerated bone cell differentiation.
222 citations
,
August 2014 in “Cell Metabolism” In this study, researchers found that mitochondrial complex I plays a crucial role in regulating innate immunity and bone remodeling, with Ndufs4 deletion causing systemic inflammation and osteopetrosis through various metabolic shifts and cellular mechanisms.
25 citations
,
May 2016 in “Progress in Biophysics & Molecular Biology” This article reviews the role of R-spondins and their receptors in bone development and metabolism, highlighting their potential modulatory effects and clinical implications for treating bone loss diseases, but reports no new clinical results.
11 citations
,
December 2018 in “Bone” This study found that a high-energy shock wave can increase osteogenic activities in human mesenchymal cells, offering insights into potential therapeutic targets for trauma-induced heterotopic ossification.
82 citations
,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
79 citations
,
January 2002 in “Nucleic Acids Research” This study found that BMP-2 activates Dlx3 gene transcription in murine keratinocytes by binding with Smad1/Smad4, suggesting a mechanism for BMP signaling's role in skin and hair follicle regulation.
September 2016 in “Journal of dermatological science” This study found that COL17 plays a key role in regulating epidermal keratinocyte differentiation and proliferation, influencing the expression of differentiation markers and cellular growth in specific conditions.
101 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.
6 citations
,
November 2020 in “Molecular and Cellular Endocrinology” This study found that androgens downregulate BMP2 in dermal papilla cells, inhibiting hair follicle stem cell differentiation, while BMP2 addition may restore hair lineage differentiation through the Wnt/β-catenin pathway.
2 citations
,
September 2017 in “Biotechniques/BioTechniques” This study developed a stable cell line model to evaluate hair differentiation activity, offering a new tool for screening drugs that promote hair growth using mouse iPS cell-derived systems.
January 2025 in “Cellular and Molecular Life Sciences” Using mouse hair follicle organoids, this study demonstrated that BMP4 plays a key role in controlling hair follicle coloration and growth, as well as directing Nestin-positive stem cells towards becoming melanocytes, the pigment-producing cells responsible for hair color.
This study found that basal cell carcinoma exhibits patterns of hair follicle differentiation but is stuck in telogen arrest, which can be rescued by adding noggin and TGF-β2 in vitro.
17 citations
,
April 2017 in “PLoS ONE” This study found that neural crest-derived hair follicle cells in mice can differentiate into osteoblast-like cells, suggesting a potential application for bone regenerative therapies.
24 citations
,
September 2019 in “Experimental cell research” This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.
September 2017 in “Journal of Investigative Dermatology” This study found that Bone morphogenetic proteins (BMPs) play a crucial role in dermal papilla cells' ability to induce hair follicle stem cell differentiation, and that androgens may impair this process by downregulating BMPs.