This study introduced a rapid rehydration approach for creating customizable, multifunctional hydrogel sensors, enabling precise detection of surface deformations and easy integration of layers, highlighting its potential for standardized and adaptable manufacturing of wearable devices.
December 2023 in “Biointerface Research in Applied Chemistry” This study used molecular docking to identify stiripentol as a potential new inhibitor of the SRD5A2 enzyme, which is targeted for treating androgen-related diseases; however, in vivo trials are needed to validate its efficacy.
December 2023 in “Pharmaceutics” In this study, nanoparticles developed with Minoxidil-loaded thiolated β-CDs showed promise for topical scalp use, as they significantly improved drug retention on hair and displayed no irritation in rabbits.
July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reports that structural and biochemical analysis of steroid 5α-reductases clarifies how they mediate steroid reduction with NADPH, potentially aiding in designing targeted therapies.
June 2010 in “Journal of Chemical Crystallography” This study determined the crystal structure and conformation of synthesized 17x-Acetoxy-pregn-4,6-diene-3,20-dione, revealing specific molecular interactions and structural details in an orthorhombic crystal system.
175 citations
,
December 1980 in “Archives of Dermatology” In this study, researchers examined two new cases of trichothiodystrophy and observed that the condition is linked to decreased synthesis of high-sulfur matrix proteins in hair.
104 citations
,
January 2005 in “Climacteric” This review discusses the pharmacological properties of progestins used in contraception and hormone replacement therapy, focusing on drospirenone's unique effects, but reports no new experimental findings.
101 citations
,
September 2006 in “Journal of Biological Chemistry” This research quantified the fidelity of human mitochondrial DNA polymerase and found it averages 1 error in 440,000 nucleotides, impacting its function related to disease and mitochondrial health.
86 citations
,
August 2011 in “Toxicological sciences” In this study, researchers found that TCDD exposure accelerated differentiation and altered gene expression in human epidermal cells, indicating the epidermal barrier as a target of TCDD-activated AHR.
75 citations
,
January 2004 in “Molecular and Cellular Biology” In this study, EDA-A2 transgenic mice exhibited multifocal myodegeneration dependent on XEDAR, suggesting a potential role for XEDAR in skeletal muscle homeostasis.
49 citations
,
September 2004 in “Journal of the European Academy of Dermatology and Venereology” This study found that careful light microscopy using fluid-mounted hair improves detection of the pili annulati phenotype, which varies widely in expression and affects hair fragility.
48 citations
,
February 1998 in “British Journal of Dermatology” This study describes a case where a patient's rapid hair loss and specific hair root changes helped diagnose thallium poisoning.
44 citations
,
February 2023 in “Cell” In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.
43 citations
,
January 1999 in “Endocrinology” This study found that cortisol increases mac25/IGFBP-rP1 expression in osteoblast-enriched cells from fetal rat calvariae, indicating transcriptional regulation which may influence IGF and insulin effects in bone.
37 citations
,
June 1996 in “Journal of cellular physiology” This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.
35 citations
,
November 2021 in “Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology” This study identified dynamic changes in DNA methylation associated with different growth stages in Tan sheep, which may offer insights to retain their valuable curly fleece as they age.
34 citations
,
June 2005 in “Developmental dynamics” This study found that Runx3 deficiency in mice affects hair type and shape, suggesting it may regulate hair formation through interactions between dermal and epidermal layers.
32 citations
,
October 2004 in “Experimental Dermatology” This study found that α-MSH acts as a modulator of inflammatory and fibrogenic responses in human fibroblastic skin cells, indicating potential therapeutic options for fibrotic skin disorders and inflammatory diseases of the hair follicle.
31 citations
,
August 2018 in “Journal of biomedical nanotechnology” This review highlights GA-mediated nanoparticles for liver-targeting drug delivery in liver cancer treatment and reports no new clinical results.
29 citations
,
November 1975 in “Clinics in endocrinology and metabolism” This article discusses the synthesis and action of testosterone and its interaction with specific receptors, reporting no new research findings.
26 citations
,
September 2018 in “Journal of Molecular Cell Biology” This study observed that Endoglin is crucial for maintaining correct hair follicle cycling and stimulating hair follicle stem cell niches through feedback interactions involving Wnt/β-catenin and Bmp/Smad signaling pathways in a mouse model.
23 citations
,
August 1989 in “American Journal of Veterinary Research” In this study, high selenium diets from different sources caused weight and hair loss in pigs, with additional hoof and coronary band problems particularly in those fed sodium selenate.
18 citations
,
October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
16 citations
,
December 2016 in “ecancermedicalscience” This study suggests that ATR-FT-IR spectral analysis of hair fibres may detect breast cancer through increased lipid content changes linked to cancer presence.
15 citations
,
May 2010 in “International Journal of Cosmetic Science” This review discusses new developments in understanding the structure and properties of keratin fiber cell membrane complexes, without reporting new experimental results.
15 citations
,
January 1987 in “Electrophoresis” This study found that electrophoretic keratin typing of head hair can identify specific polypeptide patterns, suggesting potential applications in genetic and forensic investigations.
14 citations
,
November 1963 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews the identification and characterization of soluble proteins in horny tissues such as calluses and psoriatic scales, but reports no new clinical results.
13 citations
,
September 2017 in “International Journal of Cosmetic Science” This study found that waving virgin human hair with thioglycerol at pH 9.0 using ammonia solution caused less damage than using thioglycolic acid, while maintaining good waving efficiency.
13 citations
,
January 2012 in “International journal of trichology” This case study describes a 14-year-old girl with pili annulati who had fragile hair, which may be due to cavities within the hair shafts as seen in electron microscopic examinations.
12 citations
,
December 1981 in “Journal of Endocrinology” This study found that α-melanocyte-stimulating hormone increased melanin production in hair follicles of moulting Siberian hamsters, whereas [8-arginine]-vasotocin inhibited melanin production without affecting tyrosinase activity.