Glycyrrhetinic Acid Functionalized Nanoparticles for Drug Delivery to Liver Cancer

    November 2018 in “ Journal of biomedical nanotechnology ”
    Fei Wu, Xiaocheng Li, Bin Jiang, Jiajie Yan, Zhenghou Zhang, Qin Jin, Wei Yu, Zhiqin Gao
    TLDR Licorice root-derived nanoparticles target liver cancer cells to improve treatment and reduce side effects.
    The document reviewed the use of glycyrrhetinic acid (GA) functionalized nanoparticles for liver-targeting drug delivery systems in liver cancer treatment. Liver cancer is a prevalent malignancy, and while chemotherapy is a primary treatment, it often leads to severe side effects like leukopenia, digestive issues, hepatic and renal dysfunction, and hair loss. GA, derived from licorice root, binds specifically to hepatocytes, making it a promising agent for targeted drug delivery. The review focused on the development and potential of GA-mediated nanoparticles using various polymer materials to enhance liver cancer therapy.
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