Formulation and Characterization of Resveratrol-Loaded Nanostructured Lipid Carriers for Use in Combination with Scalp Cooling Therapy to Mitigate Chemotherapy-Induced Follicular Cytotoxicity and Hair Loss

October 2025 in “ Journal of Drug Delivery Science and Technology ”

Ana-Maria Totea, Anita C. Thomas, Nikolaos T. Georgopoulos, Barbara R. Conway

resveratrol nanostructured lipid carriers scalp cooling therapy chemotherapy-induced alopecia antioxidants hair follicles propylene glycol dicaprylate NLCs CIA

Studysummary This study suggests that combining scalp cooling with resveratrol-loaded nanoparticles effectively protects hair follicles from chemotherapy-induced damage, highlighting a potential method to prevent hair loss during cancer treatment.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study developed resveratrol-loaded nanostructured lipid carriers (NLCs) to enhance the effectiveness of scalp cooling therapy in preventing chemotherapy-induced alopecia (CIA). By optimizing formulation parameters, including particle size and stability, the NLCs were designed to deliver antioxidants directly to hair follicles, potentially reducing follicular damage. The optimal NLCs had a particle size of approximately 171 nm and a polydispersity index of 0.19, with propylene glycol dicaprylate providing the best stability. This combination approach could improve patient quality of life by mitigating CIA, though further studies are needed to evaluate its effectiveness in clinical settings.

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