1P-230: Synthesis and In Vitro Characterization of 68Ga Labeled Fe3O4 Nanoparticles for Drug Delivery

    January 2016 in “ 한국공업화학회 연구논문 초록집 ”
    문미미, 박승일, 김병철, 유국현
    TLDR The nanoparticles show promise for cancer treatment and diagnosis with fewer side effects.
    The study focused on the synthesis and in vitro characterization of 68Ga-labeled Fe3O4 nanoparticles for drug delivery, aiming to reduce side effects like vomiting and hair loss associated with traditional drug uptake. The nanoparticles were modified with citric acid and hydrazine, allowing them to serve dual purposes as diagnostic imaging agents in PET and MRI, and as carriers for the antineoplastic agent Doxorubicin for cancer treatment. The 68Ga-Hydrazine-Citric acid-Fe3O4 nanoparticles demonstrated potential synergistic features, combining magnetic behavior and radioactivity for diagnosis with cytotoxicity for treatment.
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