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In this perspective, recent advances in regenerative medicine, including bioartificial substitutes and engineered in vitro platforms, are reviewed for their potential to restore human hair follicles, highlighting new technologies like 3D printing, hair-on-a-chip models, and stem cell-derived organoids.

This study observed that tissue-engineered skin, using VEGF165 gene-modified cells embedded in astragalus polysaccharide-containing 3D printed scaffolds, enhanced early vascularization, and collagen and hair follicle regeneration, leading to improved skin repair in nude mice with full skin defects.

This study found that probiotic-functionalized silk fibroin/alginate scaffolds, loaded with Lactobacillus casei, promoted scarless wound healing and hair follicle regeneration in infected wounds in rats.

This review examines various methods to enhance the functionality and therapeutic potential of mesenchymal stem cells for clinical use, highlighting both advancements and ongoing limitations, without presenting new clinical results.

This study developed a hair-on-a-chip model that supports the maturation of hair-follicle-like tissue under long-term culture conditions, suggesting its promise for studying hair regeneration and testing scalp-targeted therapies.

A single medium, PRIME AIRLIFT, supports better human hair follicle formation in grafts.

This study developed a rapid, cost-effective three-dimensional skin equivalent model using human dermal fibroblasts, collagen, and hair follicles, which closely resembles natural human skin and can be used for autologous transplantation.

This study investigated how different 3D bioprinted scaffold structures affect immune responses and hair growth in mice, finding that moderate immune response induced by certain structures stimulates hair growth, while excessive immune response can hinder hair follicle development.

This study developed a multifunctional 3D-printed hydrogel scaffold, SH-EGCG, that showed promising results for repairing infected diabetic wounds; in lab and animal tests, it demonstrated antibacterial activity, enhanced wound healing, and improved tissue regeneration and remodeling through various supportive mechanisms.

This study investigated nanocomposite scaffolds made from alginate, chitosan, and graphene oxide to promote the proliferation of spermatogonial stem cells, finding the ALGCS/GO30 scaffold to be particularly effective due to increased proliferation markers and PLZF protein expression compared to controls.

This study found that pyramidal neural precursors best grew neurites on matrigel, while neural stem cells differentiated directionally on aligned fibrin, suggesting the importance of biomaterial selection for cell culture.

This study found that hair follicle stem cells show good biocompatibility with a heterogeneous bladder acellular matrix in vitro and in vivo, supporting potential use in bladder repair.

This study found that murine epidermal stem cells implanted subcutaneously in a biodegradable carrier could survive and differentiate into structures resembling native dermis without significant rejection in recipient mice.

This paper critically reviews recent advances in the use of keratin-based biomaterials, highlighting their potential applications in wound healing, drug delivery, and tissue regeneration due to their biocompatibility, biodegradability, and ability to support cell growth.

This study introduces a new biomimetic double wound mask designed to promote scarless healing by coordinating multiple biological pathways and providing enhanced protection and nourishment to wounds.

In this study, peptide-based nanoparticles were successfully used to deliver the CRISPR-Cas9 system into cancer cells, effectively targeting and editing KRAS mutations, suggesting promising therapeutic potential for cancer treatment.

This study demonstrated that a wearable bioelectronic patch with combined therapy significantly accelerated chronic wound healing in a rodent model by monitoring and treating wounds noninvasively.

This editorial discusses the impact of 'Industry 4.0' on laboratory research, highlighting innovations like advanced software and directed enzyme evolution that promise to revolutionize biological understanding and research methods but provides no new experimental data.

This article discusses key surgical techniques for optimal graft growth in hair transplantation and presents no new research findings.

This study found that transplanting genetically modified dermal fibroblasts into full-thickness skin defects in rats led to the formation of hair follicles with mature pilosebaceous systems by 16 weeks.

This article reviews advancements in burn care, emphasizing early wound excision's role in decreasing morbidity and mortality, but it reports no new clinical findings.

This review discusses recent advancements in light-based bioelectronic devices for health monitoring and therapy, summarizing key technologies and highlighting challenges and opportunities without reporting new clinical results.

Keratin-based hydrogels from human hair and wool are promising for wound dressings and are more eco-friendly.

This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

This study demonstrated that Reverse Protein Engineering can decrease the size of Firefly Luciferase from 550 to less than 80 amino acids, but further research is needed to ensure these smaller peptides retain bioluminescent activity.

This review discusses the role of extracellular vesicles as therapeutic agents for wound healing and highlights the need for further research into their clinical applications.

In this study, a collagen sponge with isogenic fibroblasts did not enhance skin graft survival or wound healing in rats, but it did promote re-epithelization, potentially inducing epithelial inclusion cysts.

This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.