research Spatial Transcriptome Profiling Reveals TGFβ-2 in Hair Follicle Progenitor Cells Is a Potential Driver of Androgenetic Alopecia
TGFβ-2 may cause hair loss in androgenetic alopecia.
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600-630 / 1000+ resultsresearch Finasteride Inhibits Epinephrine Synthesis in Humans: Implications for Sexual Dysfunction
Finasteride may cause sexual dysfunction by reducing epinephrine levels.
research TGFβ and Cancer Metastasis: An Inflammation Link
TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
research Development of Varietal Assembly and Cultivation Techniques of Antioxidant Corn as Functional Food
Antioxidant-rich maize varieties can improve health and need local support for widespread farming.
research Pharmacological BACE1 and BACE2 Inhibition Induces Hair Depigmentation by Inhibiting PMEL17 Processing in Mice
Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.
research The Long Road Traveled in Hematopoietic Stem Cell Gene Therapy
The FDA approved the first gene therapy for a blood disorder after overcoming early challenges and demonstrating patient benefits.
research The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice
Researchers generated transgenic mice with the upstream regulatory region (URR) of human papillomavirus type 11 linked to the Escherichia coli beta-galactosidase gene to study hair-specific gene expression. They found that the reporter gene was specifically transcribed in the epithelial cells of the hair bulge region, with expression beginning after birth and not during embryogenesis. The study also revealed that treatments with dexamethasone and ultraviolet B increased the number and intensity of hair follicles expressing the reporter gene, while phorbol myristate acetate and progesterone did not have this effect.
research Repurposing of Approved Cardiovascular Drugs
Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.
research Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes
Using low-dose IL-2 to increase regulatory T cells might be a safe way to treat type 1 diabetes without severe side effects.
research Why Were Sardinians the Shortest Europeans? A Journey Through Genes, Infections, Nutrition, and Sex
Sardinians were historically short due to a mix of genetics and factors like disease and poor nutrition, but recent height increases suggest better living conditions had a bigger impact.
research Erythrocyte Deformability and Hereditary Elliptocytosis
Hereditary elliptocytosis causes elongated red blood cells and can lead to mild or no symptoms.
research In This Issue
Genetically repaired stem cells may treat certain genetic diseases, Th17 cells are key in fighting systemic fungal infections, hair loss in AGA is due to progenitor cell loss, and α-synuclein transfer might contribute to Parkinson's disease progression.
research Reporting on Adverse Clinical Events
Certain medications can reduce mortality risk in COPD patients, but others can increase risks of cardiovascular issues, postoperative delirium, and other adverse effects.
research Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids
This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.
research A Comparison of Minoxidil and Hydralazine in Non-Azotemic Hypertensives
Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.
research Minoxidil in the Management of Intractable Hypertension
Minoxidil significantly lowers blood pressure in patients with hard-to-treat hypertension, but can cause fluid retention and excessive hair growth.
research Oral Medications for Central Serous Chorioretinopathy: A Literature Review
Some oral medications may help treat central serous chorioretinopathy, especially eplerenone, but more research is needed.
research Association Between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends
Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.
research Phytochemical Analysis of Eclipta Prostrata L. Leaves
Eclipta prostrata leaves contain various compounds with medicinal properties.
research Characterization of Distinct Microbiota Associated With Androgenetic Alopecia Patients Treated and Untreated With Platelet-Rich Plasma
PRP treatment helps hair growth and rebalances scalp bacteria in androgenetic alopecia patients.
research Retinal Vasculitis With Libman-Sacks Endocarditis as Presenting Features of a Systemic Lupus Erythematosus With Antiphospholipid Antibody Syndrome Patient
A young woman with visual issues and other symptoms was diagnosed with lupus and antiphospholipid syndrome, and improved with treatment.
research Analysis of Finasteride Treatment and Its Withdrawal in Rat Hypothalamus and Hippocampus at Whole-Transcriptome Level
Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.
research Non-Coding Double Stranded RNA Induces Retinoic Acid Synthesis and Retinoid Signaling to Control Regeneration
Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.
research Skin Signs Due to Starvation
Skin changes can indicate starvation and nutritional deficiencies in anorexia nervosa.
research Minoxidil
Oral minoxidil may slow male pattern baldness and cause body hair growth, but hair loss can happen after stopping it.
research Drug News
The FDA approved a new breast cancer treatment, found flu shots may reduce heart risks, questioned the safety of fast-tracked drug approvals, showed statins don't help with certain pneumonia, and approved a new dementia imaging agent.
research Dermatologic Therapy: December 1987 to December 1988
New skin treatments in 1987-1988 showed effectiveness for various conditions, but some had side effects or risks.
research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells
β-catenin is essential for stem cell activation and proliferation in hair follicles.
research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.