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Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.

Some skin tumors may start from hair follicle stem cells.

Dr. Connelly agrees that linear basal cell carcinomas might be more aggressive but highlights the study's lack of clear criteria to identify them.

Basal cell carcinomas may differentiate similarly to hair follicles and could be influenced by hair cycle-related treatments.

Activating Notch signaling can kill basal cell carcinoma cells.

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.

BerEP4 and CD34 staining can help tell apart tricholemmoma from basal cell carcinoma.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

The extracellular matrix affects where tumors can start in the body.

Most people with basal cell carcinoma on their head or neck were 60-70 years old, and it often came back even after being fully removed, especially in certain areas and types.

Photodynamic therapy was effective in treating multiple scalp basal cell carcinomas with minimal side effects and good cosmetic results.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

People with myotonic dystrophy type 1 tend to develop basal cell carcinoma at a younger age but not more frequently than others.

Mohs micrographic surgery is effective for early-stage non-melanoma skin cancers on the lips, with basal cell carcinoma more common on the upper cutaneous lip and squamous cell carcinoma more common on the lower vermilion lip.

Men are more likely to have larger basal cell carcinomas and squamous cell carcinomas, while women have more superficial basal cell carcinomas and tumors on their legs and central face.

Scalp basal cell carcinoma may be more aggressive and harder to treat than other types, requiring special attention and further research.

A man with myotonic dystrophy type 1 had 28 skin cancers, suggesting a link between the disease and skin cancer, emphasizing the need for sun protection and regular skin checks.

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

The treatment was ineffective in humans.

The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.

Markers CRABP1, Nestin, and Ephrin B2 are present in skin cancer environments and may influence their development.

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.

Activin increases skin tumor formation, skin Tregs help hair growth, lymph-node removal doesn't improve melanoma survival, cells can revert to stem cells in wound healing, and skin bacteria produce peptides that may treat infections.

The document concludes that side effects from Smoothened inhibitor drugs for skin cancer are reversible and can be managed with a team approach to maintain quality of life.

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.