August 2023 in “Journal of analytical & pharmaceutical research” In this study, microneedle-assisted human basic fibroblast growth factor therapy was reported to significantly improve hair regeneration in both male and female patients with androgenetic alopecia, alopecia areata, and telogen effluvium, showing greater effectiveness in males.
July 2023 in “The Keio Journal of Medicine” In this review, researchers highlighted the prevalence of hereditary hair diseases in the Japanese population, emphasizing the significant impact of LIPH gene variants on autosomal recessive woolly hair and the importance of continued research to better diagnose and manage these disorders.
June 2023 in “The Journal of Dermatology” This abstract provides supplementary materials and directs queries to the corresponding author but presents no new research findings.
In this study, the researchers identified that perturbing both AKT1 and MDM2 significantly reduces epithelial-mesenchymal transition in melanoma, proposing Cialis and Finasteride as potential therapeutic candidates with favorable properties for managing aggressive melanoma.
May 2023 in “Frontiers in Cell and Developmental Biology” This review outlines the potential of using human pluripotent stem cells for hair follicle bioengineering, detailing current HF morphogenesis and cycling knowledge, various cell sources, and strategies using iPSCs, while discussing the challenges and prospects for therapeutic use in addressing hair loss.
This review highlights that nanotechnology offers promising avenues for enhancing drug delivery and developing new therapeutic strategies for androgenetic alopecia, though challenges remain in clinical translation and the need for long-term safety studies.
May 2023 in “Pharma innovation” This review discusses PUFA-rich oil seeds and microencapsulation techniques but reports no new clinical results; the authors highlight microencapsulation as a promising method to protect PUFAs from oxidation.
April 2023 in “Clinical theriogenology” This report highlights the usefulness of specific diagnostic procedures, including penile/preputial cytology and transabdominal ultrasonography, in diagnosing cryptorchidism and Sertoli cell tumors in dogs with generalized skin conditions.
April 2023 in “Journal of Investigative Dermatology” In this study, researchers observed distinct aging signatures in mouse keratinocytes, with increased expression in older mice, and noted relevant pathway changes that were also evident in human skin, suggesting potential insights into intrinsic skin aging.
This chapter reviews nanocarriers for acne therapy, highlighting their ability to reduce lesions and inflammation while improving the safety and effectiveness of treatment, though no new clinical results are reported.
January 2023 in “International Journal of Pharmaceutical Research and Development” This review discusses alopecia, its pathophysiology, nanotechnology-based drug delivery systems, and related quality of life issues, without reporting new clinical results.
This review explores the causes and diagnostic methods for androgenetic alopecia but reports no new clinical results, underlining the importance of developing new treatments.
May 2022 in “International Journal of Biochemistry Research and Review” The researchers characterized a plant-based biotin supplement, SesZenBioTM, from Sesbania agati leaves, predicting it may enhance hair follicle growth more effectively than synthetic biotin based on molecular interactions and its biotin content.
February 2022 in “INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH” This study reviewed 44 clinical trials and found that home-based laser devices are effective for short-term hair removal and skin rejuvenation, with common side effects including erythema and edema; additional trials are needed to confirm safety and efficacy.
January 2022 in “Social Science Research Network” In this study, researchers developed a long-lasting antibacterial coating for medical implants by anchoring silver nanoparticles onto polyamide surfaces, demonstrating potential to improve implant safety and effectiveness by reducing infection and inflammation.
January 2022 in “Journal for ReAttach Therapy and Developmental Diversities” This study suggests that an Ayurveda-based regimen including Guduchi, Ashwagandha, and Curcumin may enhance quality of life and is safe for breast cancer patients receiving conventional therapy.
June 2021 in “International Journal of Ayurvedic Medicine” This study found that humulen, a phytoconstituent of Cyperus Rotundus Linn., showed the highest binding affinity in molecular docking with the 5 α reductase enzyme, suggesting potential anti-androgenic effects for hirsutism treatment.
June 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” The researchers reported that basement membrane heterogeneity, especially laminin α5 composition, plays a critical role in distinct inter-tissue interactions and hair cycle regulation in mouse hair follicles.
May 2021 in “The FASEB Journal” This study presents the crystal structure of human SRD5A2 with finasteride and reveals insights into its enzyme catalysis and inhibition mechanisms, which may inform drug development.
November 2020 in “The Royal Society of Chemistry eBooks” This book discusses the development and applications of peptide-based biomaterials for healthcare, but it reports no new research findings.
September 2020 in “Research Square (Research Square)” This study observed that specific genes in cashmere goat skin exhibit a seasonal rhythm, potentially adapting to environmental light changes, which may affect downstream gene expression and physiological processes.
This study identified the combination of NCBP3, SDHA, and PTPRA as stable reference genes for normalizing gene expression in goat skin tissue research.
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.
January 2020 in “Der Pharmacia Lettre” This review discusses natural remedies and nanoparticle formulations for alopecia management and reports no new clinical results, emphasizing potential benefits of herbal treatments over synthetic therapies.
November 2019 in “Neuro-oncology” This study found that using rind-based dosimetric techniques in brain irradiation significantly reduced scalp dose and alopecia compared to standard treatment plans, with 60% of patients experiencing no hair loss.
This study found that rosemary essential oil can be incorporated into an aromatherapy massage cream, with different oil and water ratios affecting its physical properties.
This case study describes a 69-year-old man with significant smoking history and radiological findings suggesting metastatic bronchogenic carcinoma with a left adrenal metastasis.
May 2019 in “Journal of clinical oncology” This Phase 1 study reported that topical application of BPM31543 was safe and well-tolerated in patients receiving taxane-based chemotherapy, with some experiencing less than 50% hair loss, suggesting potential efficacy in reducing chemotherapy-induced alopecia, although no maximum tolerated dose was identified.
March 2019 in “Digital Access to Scholarship at Harvard (DASH) (Harvard University)” This study found that soy-based nanofibrous scaffolds enhanced wound closure and tissue regeneration via the ER-β pathways in both mouse and human skin, suggesting a potential for effective wound healing applications.
This review discusses advancements in hair transplantation techniques and treatments for androgenic alopecia, highlighting the role of finasteride, minoxidil, and emerging stem cell research, but reports no clinical results.