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In this study, stress hormone CRF was found to inhibit hair growth, suggesting that the HPA axis is functional in human dermal papilla cells and contributes to hair loss under stress conditions.

This study showed that the stress hormone CRF inhibits hair growth and induces hair loss by affecting both the proliferation of human dermal papilla cells and hair follicle function.

This study suggests that the elevated stress hormone response in adolescent male rats may involve increased conversion of testosterone to estradiol at the adrenal cortex level.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

Hair cortisol is a reliable long-term stress marker during pregnancy.

This study introduces the concept of a "gut–brain–skin axis" where ingesting a specific Lactobacillus strain in mice may reduce stress-induced skin inflammation and hair growth inhibition.

This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.

This study identified that spermidine-mediated activation of eIF5A by hypusination plays a significant role in Arabidopsis thaliana growth, flowering time, stress adaptation, and development, including changing root and aerial architecture.

This review discusses the role of gut steroids in communicating with the gut microbiota and their potential implications in treating gastrointestinal disorders and related brain conditions, suggesting new perspectives on steroid molecules as therapeutic agents.

This study found that the IL-33/ST2 axis may protect against skin carcinogenesis by promoting cross-talk between epithelial cells and regulatory T cells to minimize mutations and contain tissue damage.

In this study, the authors found that inhibiting Cdc42 activity with CASIN restored hair follicle stem cell function and hair growth in aged mice, suggesting potential for treating aging-related hair regeneration issues.

This review discusses the gut-brain-skin axis and its role in skin diseases, advocating for treatments that integrate gut microbiota, mental health, and dietary interventions, but reports no new clinical results.

Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.

This review discusses the complex mechanisms behind acne vulgaris and suggests that dietary modification, along with pro- and prebiotics, may influence its pathogenesis by addressing stress-induced skin inflammation.

The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.

This study observed that levothyroxine therapy in men with autoimmune hypothyroidism was less effective at reducing thyroid antibodies and hormone disruptions in those with early-onset androgenetic alopecia compared to those without hair loss.

This case study reports the clinical features of triple H syndrome in a 25-year-old man, including ACTH deficiency, alopecia universalis, and anterograde amnesia, which were improved with hydrocortisone treatment.

This study found that Hydroxypinacolone Retinoate (HPR) may alleviate UV-induced skin photoaging by enhancing collagen synthesis, reducing degradation, and modulating inflammatory and oxidative responses in a dose-dependent manner.

This study found that the GPRC6A-Duox1 signaling pathway influences hair cycle progression and testosterone-mediated hair loss in mice, suggesting that disruption of this pathway leads to resistance against testosterone-induced hair loss and longer anagen phase duration.

In this study, Dodatek A operationalizes the Functional Androgen Axis framework by defining three system-level indices and an efficiency metric to describe androgen function, incorporating key methodological improvements and acknowledging significant limitations for future empirical validation.

This research presents the Dodatek A model, elaborating on androgen function through new mathematical indices and methodological improvements, shifting focus from serum hormone concentrations to system interactions to better describe androgen activity comprehensively.

This study concluded that the CXCL12–CXCR4 signaling pathway significantly contributes to hair loss in androgenetic alopecia and alopecia areata by promoting inflammation and fibrosis, whereas inhibiting this pathway can restore hair growth and follicle health.

This review found that microbiota-targeted interventions, particularly certain strains of probiotics, are associated with improvements in skin conditions, most notably in pediatric atopic dermatitis, but their efficacy varies across other dermatological diseases.

Lactiplantibacillus plantarum ZJUIDS51 can help regrow hair and improve scalp health in androgenic alopecia.

In this narrative hypothesis-driven overview, the authors propose reframing rosacea as a neuroimmune disorder, highlighting the interconnected role of the skin-gut-brain axis, particularly central nervous system involvement alongside gut microbiota and neurogenic inflammation, to emphasize the need for multidisciplinary therapeutic approaches.

In this review, researchers examined advanced sensing technologies and bioelectronic interfaces that could improve understanding of the skin–brain axis, highlighting challenges and strategies for integrating these platforms into models for studying skin and neural interactions.

In this study, researchers observed that DHEA-induced PCOS rats experienced significant changes in gut microbiota and metabolic profiles, particularly affecting steroid and lipid metabolism, suggesting the gut-ovary axis may play a role in the pathogenesis of PCOS.

This systematic review reported that probiotics, prebiotics, synbiotics, postbiotics, and dietary supplements may improve hair density and reduce dandruff severity in individuals with scalp disorders, potentially by modifying inflammation, oxidative stress, and microbiota composition; however, variability across studies limits the strength of these conclusions.

This review highlights the critical role of iron in skin functions and suggests potential dermatologic therapies targeting the iron-skin axis.

Androgens reduce THY1 in skin cells, leading to less fat, more fibrosis, and worse healing in males.