Possible Intermediary Role of Ghrelin in Seborrhea

The document hypothesized that gastroesophageal reflux disease (GERD) might affect sebaceous gland activity and lead to seborrhea through the hormone ghrelin's influence. It proposed that elevated ghrelin levels during GERD could trigger an HPA-like axis in the skin, causing increased CRH expression in sebaceous glands and stimulating lipogenesis, which could result in oily skin. This hypothesis was based on the established connection between the skin and gastrointestinal tract, prior evidence linking gastrointestinal issues with sebaceous gland disorders, and the functions of ghrelin and CRH. The authors called for further studies to assess ghrelin levels in GERD and seborrhea patients and to monitor sebum changes following gastric reflux treatment.