48 citations
,
September 2017 in “Frontiers in Bioscience” This review explores the role of nanotechnology in wound healing, highlighting its potential through antimicrobial properties, selective inflammatory action, angiogenesis promotion, and its use in drug and gene delivery.
48 citations
,
December 2004 in “Differentiation” This study found that cultured dental papilla cells from various mammals can induce hair follicle regeneration and influence tissue formation, with outcomes dependent on donor age, tooth type, and host environment.
47 citations
,
September 2015 in “Journal of Drug Delivery Science and Technology” This article reviews various strategies, primarily developed by the Turin University Pharmaceutical Technology group, for increasing entrapment efficiency of hydrophilic molecules in nanoparticulate systems and reports no clinical results.
47 citations
,
November 2012 in “Expert Opinion on Therapeutic Patents” The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
45 citations
,
May 2003 in “Journal of Cell Science” This study found that α3β1-integrin is crucial for maintaining normal hair follicle morphology in mice, as its deficiency leads to severe abnormalities despite not affecting interfollicular epidermal differentiation.
44 citations
,
June 2018 in “Journal of Cellular Physiology” This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.
43 citations
,
July 2019 in “Stem Cells International” This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.
43 citations
,
June 2016 in “Clinics in Plastic Surgery” This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.
38 citations
,
September 2017 in “Oncologist” This source reports that scalp cooling is currently the only safe and FDA-cleared method to potentially reduce chemotherapy-induced hair loss, with about a 50% chance of maintaining sufficient hair to avoid needing a wig.
36 citations
,
October 1996 in “Dermatologic Clinics” In this study, a methanol extract of Eclipta alba was found to have dose-dependent hair growth-promoting activity in C57BL6 mice.
34 citations
,
February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.
32 citations
,
February 2017 in “Oncotarget” This workshop review discusses the dual role of cellular senescence in cancer, highlighting both its anticancer effects and pro-tumorigenic potential, while reporting no new research results.
32 citations
,
January 2005 in “Advances in Biochemical Engineering / Biotechnology” This review discusses the unique capacity of fetal skin to heal wounds without scarring and notes that while many factors have been identified, the complete mechanism of fetal wound healing remains unclear.
31 citations
,
September 2013 in “Stem Cells” This study suggests that canonical BMP signaling, particularly involving Smad1 and Smad5, plays a critical role in hair follicle stem cell regulation and hair morphogenesis, with distinct roles from pSmad8.
30 citations
,
December 2017 in “Advanced Healthcare Materials” This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.
28 citations
,
January 2013 in “Stem cells” This study found that the CD44(+) ALDH(+) population of neonatal human keratinocytes exhibited enhanced stem cell properties, including significantly increased long-term epidermal regeneration and multipotency, compared to unfractionated cells.
27 citations
,
October 1999 in “Experimental and Molecular Pathology” This article reviews potential animal models for studying androgenetic alopecia and reports no new experimental results; the authors highlight the need for further development of rodent models.
26 citations
,
December 2016 in “Pharmacology & Therapeutics” This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.
26 citations
,
February 2012 in “Journal of Investigative Dermatology” This study found that dermal papilla cells from human hair follicles can be reprogrammed into induced pluripotent stem cells, but their efficiency is similar to that of fibroblasts, unlike in mice.
26 citations
,
January 1994 in “Clinics in Dermatology” This article reviews advancements in burn care, emphasizing early wound excision's role in decreasing morbidity and mortality, but it reports no new clinical findings.
24 citations
,
December 2014 in “International Journal of Molecular Medicine” In this study, researchers found that petroleum ether extract of Eclipta alba significantly stimulated follicular keratinocyte proliferation and reduced TGF-β1 expression in nude mice, suggesting potential use for certain types of alopecia.
24 citations
,
February 1987 in “Drugs” Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.
23 citations
,
January 2022 in “Biomaterials Science” Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.
23 citations
,
December 2020 in “Frontiers in Cell and Developmental Biology” This review explores recent insights into how intrinsic gene oscillations and molecular interactions in hair follicle stem cells contribute to their regenerative potential, with potential implications for regenerative medicine, but reports no new clinical results.
23 citations
,
September 2018 in “Journal of Investigative Dermatology” This study reported that treating wounds with a hydrogel from acellular porcine adipose tissue and adipose-derived stem cells may significantly enhance wound healing and regeneration by promoting new adipocyte formation.
23 citations
,
June 2015 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.
23 citations
,
March 2001 in “Clinics in dermatology” This study found that 363 genes were differentially expressed in alopecia areata skin compared to non-lesional skin, suggesting T-cell mediated immune responses and distinct gene profiles related to the disease's stage.
21 citations
,
October 2018 in “European Journal of Pharmacology” This review discusses the mechanisms underlying chemotherapy-induced neuroinflammation and reports no new clinical results, emphasizing the need for a better understanding to improve management of chemotherapy side effects.
21 citations
,
January 2018 in “The Korean Journal of Physiology and Pharmacology” This study found that human umbilical cord blood mesenchymal stem cells promoted hair growth by advancing anagen onset and increasing hair follicle regeneration in an in vivo model.
21 citations
,
October 2009 in “Biochemical Engineering Journal” This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.