Mechanisms Underlying Select Chemotherapeutic-Agent-Induced Neuroinflammation and Subsequent Neurodegeneration

    October 2018 in “ European Journal of Pharmacology ”
    Fleur A. McLeary, Arie Davis, Santosh Rudrawar, Anthony V. Perkins, Shailendra Anoopkumar‐Dukie
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    Studysummary This review discusses the mechanisms underlying chemotherapy-induced neuroinflammation and reports no new clinical results, emphasizing the need for a better understanding to improve management of chemotherapy side effects. Our plain-language summary of this paper — not a Tressless recommendation.
    The document reviews the connection between chemotherapy-induced neuroinflammation and neurodegeneration, emphasizing the role of chemotherapeutic agents in neurotoxicity and peripheral toxicities. It presents evidence linking neurodegeneration to neuroinflammation and discusses the impact of chemotherapy-related adverse effects on patients. The review suggests that understanding the mechanisms of neurotoxicity and neuroinflammation could improve side effect management. It highlights the role of glial cells in neuroinflammation and the chronic consequences, such as neurodegenerative diseases. The document also explores the potential neuroprotective role of NSAIDs, citing studies that show reduced neuroinflammation and cognitive impairment with their use, although it calls for more research to confirm these benefits. Additionally, it discusses chemotherapy-induced cognitive impairment (PCCI), correlating it with increased inflammatory markers and suggesting neuroinflammation as a potential mechanism behind PCCI and other central nervous system toxicities from chemotherapy.
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