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This review discusses genetic and pharmacogenetic insights, along with RNA interference technologies, for developing personalized therapies for androgenetic alopecia, yet presents no new clinical results.

This abstract contains only supplementary material information and reports no new research findings.

In this study, activated platelet-rich plasma injections significantly increased hair count, density, and the anagen/telogen ratio in men with androgenetic alopecia, compared to placebo, suggesting it as a safe alternative to medical treatments for early-stage alopecia.

PRP may help with hair loss and improve hair quality with few side effects, but more research is needed.

This study suggests that the PPP2R3C gene may confer susceptibility to psoriatic arthritis and psoriasis vulgaris in Chinese patients, with additional possible associations involving IL-23R, ERN1, IFIH1, and KIF3A genes.

This study found that men with early-onset androgenetic alopecia had significantly larger prostate volumes and lower urinary flow rates compared to healthy controls, suggesting a possible link between AGA and prostate-related urinary symptoms.

SFRP-4 might be an early indicator of diabetes and hypertension in men with androgenic alopecia.

This study describes androgenetic alopecia as a common non-scarring hair loss condition primarily influenced by genetic factors and androgen sensitivity, notably impacting psychosocial well-being, especially in females and younger males seeking treatment.

This study concluded that GLCAT14A-C genes are crucial for the function of glucuronic acid transfer to AGPs in Arabidopsis, affecting various growth and reproductive traits such as seed germination and root hair growth.

This study found that the dietary supplement RJ-SP4AGA significantly improved hair growth and reduced hair loss in post-menopausal women with androgenetic alopecia over 16 weeks.

This study suggests that variations in CAG repeat numbers in the androgen receptor gene may not significantly influence the risk of androgenetic alopecia in Korean males.

This study found that the succinate receptor, GPR91, plays a crucial role in the progression of androgenetic alopecia by affecting the immune system and hair follicle biology, and targeting it may offer new therapeutic strategies.

Gene variation affects prostate issues and hair loss.

This article discusses various treatments for androgenetic alopecia and reports no new clinical results, noting the condition's aesthetic and psychological impact.

This study found that among men with androgenetic alopecia, the M-type pattern, either isolated or combined with others, was observed most frequently, using the BASP classification.

AGC2-1 protein is essential for root hair growth in Arabidopsis.

This study found that women with androgenetic alopecia demonstrated higher androgen receptor gene expression compared to controls, with a correlation found between higher AR expression and fewer CAG repeats in the AR gene.

This study found PRP treatment significantly increased hair count and anagen hairs in male patients with androgenetic alopecia, but there was no correlation between therapeutic response and platelet or growth factor levels.

This study suggests that the AGA risk haplotype in Europeans was driven to high frequency by positive selection, likely associated with a variant in the EDA2R gene.

This study found that the penta-peptide Gly-Pro-Ile-Gly-Ser increased the proportion of thick hair and improved baldness appearance in Japanese men with androgenetic alopecia.

In this study, the authors developed a novel PROTAC named dAR-6–1, which demonstrated superior hair regeneration in an AGA mouse model compared to minoxidil, highlighting its promise as a therapy due to potent AR degradation and excellent skin permeability.

This study suggests that a specific short sequence repeat in Malassezia restricta may be linked to increased colonization and the development or exacerbation of androgenetic alopecia.

This study found that a lower number of GGC sequences in the androgen receptor gene was associated with better clinical response to finasteride in male androgenetic alopecia patients.

In this study, researchers administered injectable platelet-rich fibrin (i-PRF) to 30 patients with androgenetic alopecia, finding an 80% response rate after 6 months, with improved hair density and reduced scalp symptoms, while reporting minimal adverse reactions.

This study evaluated the effects of autologous micrografts for androgenetic alopecia, reporting moderate improvements in hair loss reduction and hair density among most patients after treatment, with satisfactory results noted in patient satisfaction and treatment tolerability.

This study found that a novel nano-engineered platform, PCA, significantly promoted hair regeneration in an androgenetic alopecia mouse model by enhancing angiogenesis and hair follicle stem cell proliferation, showing promise for future hair regrowth treatments.

This article presents a case study of a 16-year-old male with GAPO syndrome, characterized by growth retardation, alopecia, pseudoanodontia, and optic atrophy, who sought dental treatment for missing teeth.

This letter comments on a randomized controlled trial by Shapiro et al that found no significant benefits of platelet-rich plasma compared to placebo for male androgenetic alopecia, highlighting issues with PRP protocol variations.

This review discusses genetic contributions to androgenetic alopecia and proposes focusing on candidate genes in genome-wide association studies, but it reports no new clinical results.

In this study, PGD2 was shown to increase testosterone production in human keratinocytes through reactive oxygen species, suggesting potential benefits of antioxidants like N-acetyl-cysteine for AGA patients.