Is SFRP-4 an Early Potential Biomarker Related to Diabetes and Hypertension in Patients with Androgenic Alopecia?

May 2018 in “ Endocrine Abstracts ”

Suleyman Hilmi Ipekci, Mehmet Sozen, Sedat Abusoglu, Suleyman Baldane, Fatma Tunçez Akyürek, Cem Onur Kirac, Ayse Gul Kebapcilar, Ali Ünlü, Levent Kebapcilar

Secreted Frizzled Related Protein-4 SFRP-4 androgenic alopecia AGA insulin resistance diabetes hypertension biomarker BMI HOMA-IR sensitive CRP HDL-cholesterol

TLDR SFRP-4 might be an early indicator of diabetes and hypertension in men with androgenic alopecia.

The study investigated the potential role of Secreted Frizzled Related Protein-4 (SFRP-4) as an early biomarker for diabetes and hypertension in patients with androgenic alopecia (AGA). It involved 41 male patients with AGA and 40 male controls. Results showed that SFRP-4 levels were significantly higher in the AGA group (median 1.50 ng/ml) compared to the control group (median 0.57 ng/ml). Additionally, SFRP-4 levels positively correlated with BMI, HOMA-IR, sensitive CRP, and night pulse rate, and negatively with HDL-cholesterol in the AGA group. The findings suggested that SFRP-4 might be an early indicator of insulin resistance, diabetes, and hypertension in men with AGA.

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