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A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

A gene called HDAC9 might be a new factor in male-pattern baldness.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Macrophages are essential for successful skin growth in reconstructive surgery.

Ketoconazole shampoo with finasteride improves hair density in men with hair loss.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Mutations in certain receptors can cause diseases and offer new treatment options.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Mesenchymal stem cells, especially injected into the skin, heal wounds faster and better than chitosan gel or other treatments.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride may improve prostate cancer treatment outcomes.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

Hormones and genes affect hair growth and male baldness.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

The T-zone on the face has more androgen receptors and produces more oil than the U-zone.