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Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

Minoxidil lowers blood pressure effectively but may cause unwanted hair growth and other side effects.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Testosterone implants in women require pharmacological dosing to be effective and are generally safe and well-tolerated.

Obesity is linked to various skin disorders, which can help with early diagnosis and prevention of long-term health issues.

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

Two sisters with rickets and hair loss had a genetic issue with vitamin D processing, and only improved when given phosphorus supplements.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Vitamin D is important for bones, hair, blood pressure, and breast development.

Dlx3 is essential for hair growth and regeneration.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Activin A and follistatin control when hair cells develop in mouse ears.

Ketoconazole shampoo with finasteride improves hair density in men with hair loss.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Common latent viruses might contribute to male-pattern baldness by disrupting cell processes that normally suppress hair loss-related proteins.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.