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Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Skin fat helps with body temperature control and has other active roles in health.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

Shrinking of oil glands in the skin is a key sign of hair loss linked to TNF inhibitor drugs and may improve if the treatment is stopped.

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

DHT may reduce inflammation caused by certain bacteria in skin cells.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

SHBG may be a useful early indicator and treatment target for PCOS.

Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.

Some Middle Eastern plants may help treat diabetes and could be alternatives to current drugs, but more research is needed.

Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Loss of Fz6 disrupts hair follicle and associated structures' orientation.

Mice with CBS deficiency are healthier on a low-methionine diet.

Ginsenoside F2 may help prevent hair loss and promote hair growth better than finasteride.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

A gene called Gk5 controls lipid production in the skin and affects hair growth.

Skin health and diseases are closely linked to metabolic processes.