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Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

The research concluded that selection significantly shaped the genetic variation of the X chromosome, with certain regions affected by past selective events.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Congenital Triangular Alopecia is a rare, non-scarring hair loss that can be surgically treated in females for cosmetic reasons.

Tiny particles called extracellular vesicles show promise for treating skin conditions and promoting hair growth.

A synthetic octapeptide may help promote hair growth and counteract hair loss.

Isotretinoin and tazarotene help treat acne, while minoxidil and finasteride promote hair growth.

New pharmaceutical biomaterials, especially nanomaterials, show promise for improving cancer treatment and disease diagnosis.

Male hormones and their interactions are crucial for male sexual development and characteristics.

Low vitamin D levels are linked to various types of hair loss, but more research is needed before using it as a treatment.

DHT reduces a cell's ability to promote hair growth, while 3D culture without DHT improves it.

Testosterone is important for male sexual traits, reproduction, muscle and bone health, blood production, and metabolism, and works both directly and after being changed into other hormones.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by blocking male sex hormones.

The document concludes that various topical treatments show promise for skin conditions like atopic dermatitis, psoriasis, and hair loss.

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

Testosterone and some of its forms can strongly stimulate oil gland growth in skin.

PRP injections help regrow hair, reduce hair loss, and increase hair thickness, but effects decrease without ongoing treatment.

Low-level laser therapy significantly increases hair density in adults with hair loss, with low-frequency treatment being more effective.

The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.

Cathepsin L is essential for normal hair growth and development.

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

Hair loss in balding individuals is linked to changes in specific hair growth-related genes.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

Hair loss in male pattern baldness involves muscle degeneration and increased scalp fat.

Over half of the adult women with acne in the study had higher than normal levels of male hormones, especially DHEA.

CIP/KIP proteins help stop cell division and support hair growth.