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Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

The document explains how male reproductive hormones work and affect the body.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Scutellaria baicalensis extract and baicalin may help prevent hair loss.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Gene mutations can cause problems in male genital development.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Sebocytes play a key role in controlling androgen levels in human skin.

High androgen levels in young women with PCOS are linked to higher blood pressure.

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

Women with PCOS have higher androgen levels that decrease with age but are still higher than in women without PCOS.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Mutations in certain receptors can cause diseases and offer new treatment options.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Finasteride may improve prostate cancer treatment outcomes.

Monascus helps prevent baldness, prostate issues, and may be a natural alternative to medications.

The letter is skeptical about the effectiveness of anti-androgen therapy for COVID-19 and calls for strong evidence from clinical trials.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.