21 citations
,
January 2017 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” This study suggests that acne is often associated with hyperandrogenemia in women, contradicting previous recommendations that acne is not linked to androgen excess disorders.
7 citations
,
September 2024 in “International Journal of Molecular Sciences” This study found that 11-oxygenated androgens were higher in women with PCOS compared to those with idiopathic hirsutism, with no difference from controls, and higher Bisphenol A levels in obese women with PCOS may worsen metabolic issues.
January 2025 in “Human Reproduction Open” This study found that approximately 26% of women with Type 1 diabetes have undiagnosed androgen disorders, with polycystic ovary syndrome being the most common, particularly in those with premenarcheal onset of diabetes.
70 citations
,
February 2012 in “Human Reproduction” This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.
352 citations
,
January 2006 in “The Journal of Clinical Endocrinology and Metabolism” This study reported that classic anovulatory PCOS was the most common androgen excess disorder, followed by mild ovulatory PCOS and idiopathic hyperandrogenism, among patients evaluated for clinical hyperandrogenism.
20 citations
,
January 2019 in “Frontiers of Hormone Research” This paper reviews the endocrinological aspects of hirsutism, focusing on the role of androgens in excessive hair growth and the related disorders, without presenting new findings.
5 citations
,
June 2020 in “Journal of Endocrinological Investigation” The study observed that women with congenital adrenal hyperplasia experience more impaired sexual functions and are more often homosexually or bisexually oriented than those with polycystic ovary syndrome.
23 citations
,
January 2016 in “Journal of Nanjing Medical University” This study found that higher BMI in PCOS patients at a Chinese clinic was associated with functional disorders of androgen excess, suggesting BMI may predict hyperandrogenism in this population.
815 citations
,
April 2010 in “The Journal of Clinical Endocrinology & Metabolism” This review examines the relationship between polycystic ovary syndrome and cardiovascular disease risk, but reports no new clinical findings; the panel calls for guidelines to prevent CVD in this population.
251 citations
,
October 2014 in “The Journal of Clinical Endocrinology & Metabolism” The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.
April 2005 in “CRC Press eBooks” Excessive androgens in women with polycystic ovary syndrome can lead to excessive hair growth and hair loss, but this might not fully explain these conditions.
80 citations
,
January 1995 in “The American Journal of Medicine” Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.
4 citations
,
September 2011 in “American Journal of Clinical Dermatology” This case series suggests that EE/CMA 0.03mg/2mg may help manage dermatological disorders related to androgen excess, as evidenced by symptomatic improvements in the four patients treated.
January 1977 in “Case Reports in Medicine” This article discusses ovarian steroid cell tumors, which can produce testosterone and manifest symptoms like hirsutism, emphasizing surgery as the primary treatment, but reports no new clinical findings.
21 citations
,
December 2007 in “Primary Care” This article reviews the challenges in treating PCOS, noting the potential benefits of insulin sensitizers on ovulatory function and pregnancy outcomes, and calls for more long-term studies on metabolic interventions.
Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.
2 citations
,
September 2004 in “Fertility and sterility” This review discusses the cosmetic and health implications of hirsutism and highlights its potential link to serious underlying disorders, but it presents no new clinical findings.
1 citations
,
November 2007 in “Humana Press eBooks” This article reviews the differential diagnosis and management approaches for androgen excess disorders, highlighting the predominance of polycystic ovary syndrome as the underlying cause and reports no new clinical findings.
1540 citations
,
October 2008 in “Fertility and Sterility” This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.
July 2023 in “Journal of Education, Health and Sport” This study found that while many women were aware of some symptoms and causes of androgen excess, there is a need to improve education on this endocrine disorder, especially among those without medical backgrounds.
78 citations
,
January 2000 in “Gynecological Endocrinology” This study found that the progestins norgestimate and dienogest may help treat clinical hyperandrogeny in women by inhibiting skin 5 alpha-reductase activity with minimal androgenic potential.
19 citations
,
July 1990 in “Cleveland Clinic journal of medicine” This article reviews endocrine therapies for androgen excess disorders, emphasizing spironolactone, estrogen, and dexamethasone as effective treatments; it reports no new clinical results.
76 citations
,
November 2009 in “Medical Clinics of North America” This article reviews the hormonal and medication-related factors associated with acne development but does not present new research findings.
December 2023 in “PubMed” In this case report, pediatric HAIR-AN syndrome with severe acanthosis nigricans was significantly improved with metformin and liraglutide treatment, suggesting that early diagnosis and supportive treatment for symptoms like unexplained acanthosis nigricans and menstrual disorders can enhance quality of life.
In this study, hyperandrogenemia was observed in 78.2% of Greek women with polycystic ovary syndrome, with testosterone being the most commonly elevated androgen and acne the most frequent clinical feature.
17 citations
,
December 2013 in “Journal of Investigative Dermatology Symposium Proceedings” This report describes two young women with severe psoriasis and alopecia universalis, highlighting the possible but unstudied association between alopecia areata and metabolic syndrome.
9 citations
,
December 2024 in “Clinical and Experimental Obstetrics & Gynecology” This review examines the impact of polycystic ovary syndrome on reproductive health, its pathophysiology, clinical manifestations, and emerging therapies, and reports no new findings; the authors emphasize the need for individualized treatment strategies.
April 2023 in “Elsevier eBooks” This review discusses the various phenotypes and systemic manifestations of polycystic ovary syndrome, including metabolic, reproductive, and psychological aspects, but reports no new clinical results.
November 2017 in “JAMA internal medicine” Women also use 5α-reductase inhibitors, and their effects differ from men.
This review outlines diagnostic and treatment approaches for hirsutism, highlighting spironolactone or cyproterone acetate with oral contraceptives as the most effective therapy, and reports no new empirical results.