November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study in live mice suggests that hair follicle regression involves apoptosis propagation towards stem cells, potentially slowed by a protective signal from the stem cells themselves.
15 citations
,
April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that A(3)B(5) downregulates melanin production and suppresses melanoma cell growth by promoting proteasomal degradation of TRP-2.
7 citations
,
February 2009 in “Cell and tissue biology” This study found that 5% Adenophora Radix extract stimulated more hair follicles and shafts in a mouse model, suggesting potential as a hair loss prevention cosmetic.
21 citations
,
April 2000 in “Journal of Cutaneous Pathology” This case report describes a 22-year-old woman with a nevoid plaque termed localized follicular hamartoma, characterized by skin-colored papules and specific cellular and structural features.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers used single-cell RNA sequencing to define and locate three distinct cell states of melanocytes in mouse skin development, potentially aiding the understanding of abnormal melanocyte differentiation.
November 2025 in “Journal of Investigative Dermatology” Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.
41 citations
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December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported that deleting the MED1 subunit from the MED complex in keratinocytes resulted in disrupted hair differentiation and cycling, leading to hair loss in mice.
34 citations
,
December 1984 in “Journal of Cutaneous Pathology” This study observed that the thinning and structural abnormalities in monilethrix-affected hair occur at the internodes due to possible periodic dysfunction of the hair matrix, particularly in the cortex.
26 citations
,
January 1992 in “Carcinogenesis” This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.
178 citations
,
April 2011 in “Journal of Clinical Investigation” This study found that the phenotype of Hedgehog/Gli-driven skin tumors in mice depends on the cell of origin, tissue context, and level of oncogenic signaling.
8 citations
,
July 2014 in “American Journal of Dermatopathology” This discussion reviews the classification and naming of cutaneous cysts, proposing that cysts typically named cutaneous keratocyst and steatocystoma should be unified under the term "sebaceous duct cyst," but it reports no new clinical results.
4 citations
,
February 2019 in “Journal of Cutaneous Pathology” This study suggests that the epigenetic marker 5-hmC may dynamically influence hair follicle bulge activation during anagen growth in mice, warranting further investigation into its role in stem cell regulation.
36 citations
,
March 2011 in “Stem Cell Reviews and Reports” 61 citations
,
March 1966 in “Archives of Dermatology” This study found that nevoid basal cell carcinomas originate in the epidermis and upper hair follicles, resembling early nonnevoid basal cell carcinoma proliferations.
19 citations
,
August 1996 in “British Journal of Dermatology” This study found that dermal papillae in alopecia areata, including clinically normal follicles, exhibited ultrastructural abnormalities that suggest an early pathological role in the disease's development.
June 2022 in “Research Square (Research Square)” This study revealed that nestin-expressing progenitor cells capable of becoming ORS keratinocytes are present during both hair follicle development and in adult hair follicles.
30 citations
,
November 2018 in “EMBO Reports” This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.
9 citations
,
December 1991 in “Annals of the New York Academy of Sciences”
December 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This entry does not provide an abstract or new research findings, so no specific results are available for summary.
December 2021 in “Research Square (Research Square)” This study found that dermal injection of M-CSF stimulated CD11b + myeloid cells can induce alopecia areata in mice by potentially activating B lymphocytes, offering insight into the disease's pathogenesis.
40 citations
,
January 1985 in “Tissue and Cell” This study found that sebum in sebaceous glands is produced from cell populations derived from peripheral progenitor cells, similarly to hair growth, without direct involvement from other peripheral cells.
September 2011 in “Clinical Biochemistry” The demineralized bone matrix scaffold is better for cell attachment than the mineralized bone allograft.
6 citations
,
March 2011 in “European Journal of Dermatology” This study observed that nestin-positive, K15-negative cells in hair follicles may play a crucial role in hair follicle regeneration in patients with alopecia areata.
13 citations
,
April 1982 in “The Journal of Dermatology” This study found that poly(adenosine diphosphate-ribose) synthesis in human skin varies by cell type and condition, with distinct patterns in psoriatic, cancerous, and normal tissues.
53 citations
,
July 1981 in “Journal of Endocrinology” In this study, α-MSH and cyclic AMP were found to stimulate melanogenesis in hair follicle cultures, while cyclic GMP and melatonin inhibited melanin production but not tyrosinase activity.
37 citations
,
March 1998 in “Lupus” This case report describes a patient with SLE and APLS who developed basaloid follicular hamartomas, which persisted despite aggressive treatment for SLE, although hair regrowth occurred.
14 citations
,
March 2015 in “Stem Cell Research & Therapy” This study indicates that ABCG2 expression identifies interfollicular keratinocyte progenitor cells in human epidermis and suggests it could help enrich these stem cells for research and treatment.
20 citations
,
April 1959 in “A M A Archives of Dermatology” Alopecia mucinosa causes red, raised skin patches and hair loss.