TLDR ABCG2 protein marks stem-like skin cells in human epidermis.
The study identified the breast cancer resistance protein (ABCG2) as a marker for clonogenic keratinocyte progenitor cells in human interfollicular epidermis. Approximately 2-3% of keratinocytes in non-hair-bearing epidermis expressed ABCG2, along with p63, β1 and α6 integrins, and keratin 14, but not CD34, CD71, C-kit, or involucrin. ABCG2-positive keratinocytes demonstrated higher colony-forming efficiency and long-term proliferation capacity compared to ABCG2-negative cells. These findings suggested that ABCG2 expression is a characteristic of interfollicular keratinocyte progenitor cells and could be used to enrich keratinocyte stem cells in human epidermis.
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