A Case of Localized Follicular Hamartoma: An Ultrastructural and Immunohistochemical Study

    April 2000 in “ Journal of Cutaneous Pathology ”
    Masaaki Morohashi, F. Sakamoto, T. Takenouchi, Takeshi Hashimoto, Osamu Tago, Masaaki Ito
    TLDR The hamartoma is an abnormal hair growth with limited development in the upper hair follicle.
    The document reported a case of a 22-year-old woman with a nevoid plaque termed localized follicular hamartoma, which appeared at puberty on one side of her face and scalp. The plaque consisted of numerous skin-colored to light brown papules, sometimes with a single hair. Histological examination revealed branched epithelial nests of squamoid and/or basaloid cells connected to the interfollicular epidermis and upper portions of hair follicles, with normal lower follicle structures. Immunohistochemical analysis showed keratin expression similar to infundibular epithelium, with S-100-positive cells in the nests and stroma, and numerous Factor XIIIa-positive dendritic cells near the nests. Ultrastructural analysis identified immature melanocytes and Merkel cells in the nests, and stromal dendritic cells with cytoplasmic processes adhering to anchoring fibrils or basal lamina. The findings suggested the hamartoma was an abortive growth of secondary hair germs with limited differentiation to the upper follicular portion.
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