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Glossary Secondary Hair Germ

cluster of cells initiating new hair growth cycle

The Secondary Hair Germ is a cluster of cells located at the base of the hair follicle, which plays a crucial role in the regeneration of hair during the hair growth cycle. These cells become active during the transition from the resting phase (telogen) to the growth phase (anagen), helping to initiate the formation of a new hair shaft.

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Research

5 / 1000+ results

research Ber‐EP4 antigen is a marker for a cell population related to the secondary hair germ

21 citations , June 2004 in “Experimental Dermatology”

This study found that Ber-EP4 immunoreactivity is present in specific areas of hair follicles across different stages of the hair cycle, particularly in the secondary hair germ, but not in mature anagen follicles.

research 1017 The prostaglandin F2α analog bimatoprost activates secondary hair germ cells to promote hair growth through two distinct signaling pathways

July 2026 in “Journal of Investigative Dermatology”

This study uncovered that bimatoprost, a prostaglandin analog, promotes hair growth by activating hair follicle progenitor cells through two pathways: the PTGFR-MAPK signaling axis and an unexpected IGF1R-PCAD-AKT signaling axis, suggesting new potential targets for treating hair disorders.

research Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

178 citations , April 2011 in “Journal of Clinical Investigation”

This study found that the phenotype of Hedgehog/Gli-driven skin tumors in mice depends on the cell of origin, tissue context, and level of oncogenic signaling.

research Clock genes, hair growth and aging

55 citations , March 2010 in “Aging”

This study found that circadian clock genes are involved in regulating the hair growth cycle, suggesting a connection between daily rhythms and the longer hair follicle cycling process.

research Basonuclin as a cell marker in the formation and cycling of the murine hair follicle

27 citations , October 1998 in “Differentiation”

Basonuclin helps identify and track hair follicle development and cycling in mice.

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Community Join

5 / 221 results

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 8 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community How much difference hair fibers and mousse make

in Styling 1459 upvotes 1 year ago

The user applies Rogaine foam, Toppik hair fibers, and Tresemme mousse to improve hair appearance and has restarted finasteride after a year off. They are considering a hair transplant and are working on self-esteem related to hair loss.

community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 1 year ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

233 upvotes 10 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

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Learn

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learn Hair Transplant

What are the risks and side effects of FUE hair transplants? Providers describe most FUE side effects, such as swelling, redness, numbness and shock loss, as temporary, but FUE is surgery and the same sources report pain, infection, folliculitis and small permanent donor-site scars. Longer-lasting problems, including visible donor-area thinning or poor graft growth, are possible and are not covered by this provider survey.
What is a hair transplant? A hair transplant is a surgical procedure that relocates hair follicles to areas of thinning.
How much does a hair transplant cost? Hair transplant costs typically range from $1,000 to $25,000 depending on various factors.
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learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas