Immunohistochemical Study on TGF-β Expression in Human Hair Follicles

    April 2007 in “ 대한피부과학회지 ”
    원종현, 주영현, 이동훈, 안지수, 김범준, 권오상, Gwanghyun Jo, 김규한, 은희철
    TLDR TGF-β1 and 2 in hair follicles may be linked to hair loss in AGA.
    This study investigated the expression of TGF-β subtypes in hair follicles of androgenetic alopecia (AGA) patients. It found that TGF-β1 was expressed in the outer area of the inner root sheath, TGF-β2 in the inner half of the outer root sheath, and TGF-β3 in the hair cortex and cuticle. In AGA patients, there was enhanced expression of TGF-β2 and type II receptor in the bald vertex area compared to the non-bald occipital area. During the catagen phase, TGF-β2 and 3 were expressed in epithelial strands and secondary hair germs, with intensified immunoreactivity of TGF-β1 and 2 in the outer root sheath. The study concluded that the expression of TGF-β1, 2, and their receptors in follicular epithelial cells might be linked to catagen induction and the development of AGA.
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