The Analysis of the Expression of TGF-Beta in Human Hair Follicles In Vivo

April 2007 in “ Linchuang pifuke zazhi ”

Chong Hyun Won, Young Hoon Joo, Dong Hun Lee, Jee Soo An, Beom Joon Kim, Ohsang Kwon, Kwang Hyun Cho, Kyu Han Kim, Hee Chul Eun

TGF-beta TGF-beta1 TGF-beta2 TGF-beta3 androgenetic alopecia catagen phase hair follicles inner root sheath outer root sheath hair cortex hair cuticle type II receptor epithelial strands secondary hair germs AGA

TLDR TGF-β1 and 2 may play a role in hair loss in AGA.

The study investigated the expression of TGF-β subtypes in hair follicles of androgenetic alopecia (AGA) patients. It found that TGF-β1 was expressed in the outer area of the inner root sheath, TGF-β2 in the inner half of the outer root sheath, and TGF-β3 in the hair cortex and cuticle. In AGA patients, there was an enhanced expression of TGF-β2 and type II receptor in the bald vertex area compared to the non-bald occipital area. During the catagen phase, TGF-β2 and 3 were expressed in epithelial strands and secondary hair germs, with intensified immunoreactivities of TGF-β1 and 2 in the outer root sheath. The study concluded that the expression of TGF-β1, 2, and their receptors in follicular epithelial cells might be related to catagen induction and the development of AGA.

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The Analysis of the Expression of TGF-Beta in Human Hair Follicles In Vivo

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