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Combining genetic and physical trait analysis improves diagnosis accuracy for monogenic diabetes.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.

Deleting MED1 in skin cells causes hair loss and skin changes.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

People with hidradenitis suppurativa often have lower vitamin D levels, weaker hip bones, and altered bone metabolism markers.

Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.

The combined Myo-inositol and D-chiro-inositol treatment improved weight, hormone levels, and skin conditions in women with PCOS.

Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

The new rodent model successfully mimics non-lean human PCOS symptoms.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Women with congenital adrenal hyperplasia have lower fertility, but with proper treatment, they can conceive successfully.

FDG PET/CT scans can change cancer treatment plans for dogs.

Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.

Small hormonal imbalances can cause significant health problems, so more sensitive testing for hormone-disrupting chemicals is needed.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.

Metabolism plays a key role in determining stem cell fate.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Finasteride doesn't affect omeprazole metabolism in Japanese people.

A 17-year-old female with adrenogenital syndrome produces very high levels of androgens, which prevent complete feminization despite high estrogen doses.