Reproductive Outcomes of Female Patients with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

January 2013 in “ Indian Journal of Endocrinology and Metabolism ”

Mouna Mnif, Mahdi Kamoun, F. Hadj Kacem, F. Mnif, Nadia Charfi, B. Ben Naceur, N. Rekik, M. Abid

congenital adrenal hyperplasia 21-hydroxylase deficiency androgen excess adrenal progesterone hypersecretion genital reconstructive surgery secondary polycystic ovaries syndrome glucocorticoid therapy CAH PCOS

TLDR Women with congenital adrenal hyperplasia have lower fertility, but with proper treatment, they can conceive successfully.

The 2013 review article analyzed reproductive outcomes in women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. It concluded that these women generally have reduced fertility, especially those with the classic salt-wasting type of CAH, due to factors such as androgen excess, adrenal progesterone hypersecretion, genital reconstructive surgery, secondary polycystic ovaries syndrome, and psychosexual issues. However, pregnancies in CAH women tend to be normal. The review highlighted that advancements in glucocorticoid therapy, surgical methods, and psychological support have led to improved fertility rates in women with classic CAH. It stressed the importance of a multidisciplinary approach from childhood to adulthood to prevent subfertility and noted that with proper management, women with CAH can successfully conceive.

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Research cited in this study

2 / 2 results

research Management of Congenital Adrenal Hyperplasia During Pregnancy

29 citations, December 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity”

With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.

research Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Pathophysiology, Diagnosis, and Treatment

49 citations, January 2010 in “International Journal of Pediatric Endocrinology”

The document concludes that Nonclassic Congenital Adrenal Hyperplasia requires personalized treatment plans to manage symptoms and fertility, with glucocorticoids being a common therapy.

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research Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review

32 citations, June 2019 in “Frontiers in Endocrinology”

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