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Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.

Larger prostate size in older men may be linked to poorer semen quality and fertility issues.

The document concludes that Hidradenitis suppurativa is often underdiagnosed, lacks definitive treatment, and requires better awareness and management strategies.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.

Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.

RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Finasteride doesn't affect erections much, but may decrease libido in men.

Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Older patients sticking to their prostate medication saw lasting health benefits.

People with hair loss may have different levels of certain hormones due to changes in hormone processing.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.

Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.

Urologists should screen for mental health issues before and during finasteride treatment.

Cell-based models help test if cosmetic ingredients really work for hair growth and skin health.

Long-term use of a drug for hair loss and prostate issues can cause metabolic problems and depression-like behavior in young male rats.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

Male-pattern hair loss is largely influenced by genetics, with key genes identified.

Ganoderma lucidum may help treat prostate cancer by blocking male hormones and slowing cancer cell growth.

Chinese medicine may help treat hair loss by affecting genes and enzyme activity.

Correcting vitamin D and progesterone deficiencies can significantly improve hair loss, acne, and BPH symptoms.

The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.

Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.

5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.

The new gel formula could improve the delivery of a hair loss treatment through the skin and might be an alternative to taking it by mouth.