ODP265 BPH, Androgenic Alopecia, and Acne – Markers of Progesterone Deficiency

November 2022 in “ Journal of the Endocrine Society ”

Svetlana Kalinchenko, Igor Nikiforov, Olga Samburskaya

androgenic alopecia vitamin D progesterone topical progesterone 5-α-reductase enzyme BPH acne hair loss topical treatment 5-alpha-reductase

TLDR Correcting vitamin D and progesterone deficiencies can significantly improve hair loss, acne, and BPH symptoms.

A study involving 6 male patients aged 21-50 with BPH, androgenic alopecia, and acne revealed vitamin D and progesterone deficiencies. Patients were treated with 20,000 IU of vitamin D and 100 mg of progesterone daily, with additional topical progesterone for acne. After 6 months, there was an 80-90% improvement in hair loss and hair growth, a significant reduction in acne severity, and improved BPH symptoms. The study suggests that correcting vitamin D and progesterone deficiencies can effectively treat these conditions, likely due to the inhibition of the 5-α-reductase enzyme by progesterone.

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