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The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

New therapies are being developed that target integrin pathways to treat various diseases.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Hirsutism can lower a woman's quality of life, causing emotional distress and affecting social and work opportunities.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

GLPLS is a rare skin condition with specific hair loss and skin symptoms.

Excessive blue light harms eye cells and disrupts sleep patterns.

Possible link between androgens and COVID-19 severity; more research needed.

The foreword introduces a medical issue discussing male hormonal health, treatments, and the effects of conditions like obesity and aging.

Latanoprost can make eyelashes longer, thicker, and darker.

COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Paeoniflorin protects brain cells by involving a specific protein and neurosteroids.

PRP shows promise for improving facial wrinkles, skin elasticity, and hair growth, but more research is needed to standardize its use and understand its effects.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Alopecia patients have less GPER-1, which might affect hair loss.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.