Invasion and Increased Expression of S100A4 and CYR61 in Mesenchymal Transformed Breast Cancer Cells Is Downregulated by GnRH

The study found that mesenchymal transformed breast cancer cells showed higher levels of S100A4 and CYR61, proteins linked to cancer cell motility, compared to non-transformed cells. Treatment with the GnRH agonist Triptorelin significantly reduced both the invasion and expression of these proteins in MCF-7-EMT and MDA-MB-231 breast cancer cells. Additionally, using antibodies against S100A4 and CYR61 decreased cell invasion, underscoring their role in cancer progression. The findings suggested that GnRH treatment could inhibit breast cancer cell invasion by downregulating S100A4 and CYR61, indicating potential for GnRH agonists as anti-metastatic therapies, although the exact mechanisms were not fully understood.